ReviewAntibiotics (Basel, Switzerland)2022
Insights in the Development and Uses of Alternatives to Antibiotic Growth Promoters in Poultry and Swine Production.
Review in Antibiotics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
101 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Behavioral responses of pigs to dietary alternatives to antibiotic growth promoters: a systematic review.Veterinary research communications · 2026Pooled it
- Fermented agricultural by-products improve growth performance in indigenous chickens in association with altered ileal microbiota, microbial functional potential, and mucosal responses.Poultry science · 2026Article
- Effects of Immunologically Active Peptides on Growth Performance, Meat Quality, Antioxidant Capacity, and Ileum Inflammation in Broilers.Veterinary sciences · 2026Article
- Wood-derived lignans magnolol and honokiol improve nutrient utilization in broilers and regulate inflammation and epithelial repair in vitro.Poultry science · 2026Article
- The potential of in-ovo probiotics to replace antibiotic growth promoters in broiler diets: Effect on performance, meat quality, cecal fermentation and oxidative stress indicators.Poultry science · 2026Article
- The Effect of Feeding Strategies Based on Flaxseed and Locally Available Plant-Derived Additives on the Growth Performance, Biochemical and Immune Blood Indices, and Antioxidant Capacity of Pigs in Sustainable Production.Animals : an open access journal from MDPI · 2026Article
- Article
- Silver-based N-heterocyclic carbene (NHC) complexes as emerging strategies against antimicrobial resistance.Archives of microbiology · 2026Review
- Oregano essential oil: a pre-harvest tool to reduce Salmonella enterica serovar Enteritidis in market-age broilers.Poultry science · 2026Article
- Antimicrobial-resistant Escherichia Coli and Salmonella in poultry production and spread and effect in the one health framework.Poultry science · 2026Review
- Potential Role of Brown Macroalgae on Pig Health: A Review.ACS nutrition science · 2026Review
- Dietary Capsiate-Producing Chili Pepper Promotes Somatic and Femoral Growth and Modulates Intestinal Immunometabolic Responses in Mice.Molecules (Basel, Switzerland) · 2026Article
- Dietary Fermented Chinese Chive Juice Improves Growth Performance and Reshapes the Fresh Meat Volatile Flavor Profile of Small-Tailed Han Sheep.Animals : an open access journal from MDPI · 2026Article
- Recent Advances in Egg White Biotechnology, Microbiology, and Quality.Comprehensive reviews in food science and food safety · 2026Review
- Composite Probiotic Fermented Feed Enhances Growth Performance and Intestinal Health in Weaned Piglets by Modulating the Gut Microbiome and Metabolome.Animals : an open access journal from MDPI · 2026Article
- Investigating the Antioxidant and Immunomodulatory Effects of Quercetin Using Porcine PBMCs as an Inflammatory In Vitro Model.Antioxidants (Basel, Switzerland) · 2026Article
- Poultry gut health: industry drivers, management determinants, and emerging research directions.Veterinary and animal science · 2026Review
- Genomic and phenotypic characterization of Enterococcus faecalis from broiler sternal bursitis: antimicrobial resistance and one health risks.Veterinary research communications · 2026Article
- Bibliometric analysis of pharmacokinetic research on the combination of norfloxacin and tylosin in poultry and reptiles.Open veterinary journal · 2026Article
- Yeast (Journal of advanced veterinary and animal research · 2026Article
41 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The overuse and misuse of antibiotics has contributed to the rise and spread of multidrug-resistant bacteria. To address this global public health threat, many countries have restricted the use of antibiotics as growth promoters and promoted the development of alternatives to antibiotics in human and veterinary medicine and animal farming. In food-animal production, acidifiers, bacteriophages, enzymes, phytochemicals, probiotics, prebiotics, and antimicrobial peptides have shown hallmarks as alternatives to antibiotics. This review reports the current state of these alternatives as growth-promoting factors for poultry and swine production and describes their mode of action. Recent findings on their usefulness and the factors that presently hinder their broader use in animal food production are identified by SWOT (strength, weakness, opportunity, and threat) analysis. The potential for resistance development as well as co- and cross-resistance with currently used antibiotics is also discussed. Using predetermined keywords, we searched specialized databases including Scopus, Web of Science, and Google Scholar. Antibiotic resistance cannot be stopped, but its spreading can certainly be hindered or delayed with the development of more alternatives with innovative modes of action and a wise and careful use of antimicrobials in a One Health approach.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.