Evidence map›Paper›PMID 35740076›Full record

ArticleAntioxidants (Basel, Switzerland)2022

Protective Effects of Emodin on Oxidized Fish Oil-Induced Metabolic Disorder and Oxidative Stress through Notch-Nrf2 Crosstalk in the Liver of Teleost

Changyou Song, Bo Liu, Hongxia Li, Yongkai Tang, Xianping Ge, Bo Liu, Pao Xu

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Biology · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Antioxidant and Anti-Inflammatory Activities of Methanol Extract ofInternational journal of molecular sciences · 2025
    Article
  8. Emodin Improves Juvenile Largemouth Bass (Animals : an open access journal from MDPI · 2025
    Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Oxidative Stress in Aquatic Organisms.Antioxidants (Basel, Switzerland) · 2023
    Article
  15. Article
  16. Dietary Supplementation ofAntioxidants (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Changyou SongKey Laboratory of Aquatic Animal Nutrition and Health, Freshwater Fisheries Research Center, Chinese Academy of Fishery Science, Wuxi 214081, China.ORCID 0000-0002-9424-3331
Bo LiuWuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, China.
Hongxia LiKey Laboratory of Aquatic Animal Nutrition and Health, Freshwater Fisheries Research Center, Chinese Academy of Fishery Science, Wuxi 214081, China.
Yongkai TangKey Laboratory of Aquatic Animal Nutrition and Health, Freshwater Fisheries Research Center, Chinese Academy of Fishery Science, Wuxi 214081, China.
Xianping GeKey Laboratory of Aquatic Animal Nutrition and Health, Freshwater Fisheries Research Center, Chinese Academy of Fishery Science, Wuxi 214081, China.
Bo LiuKey Laboratory of Aquatic Animal Nutrition and Health, Freshwater Fisheries Research Center, Chinese Academy of Fishery Science, Wuxi 214081, China.
Pao XuKey Laboratory of Aquatic Animal Nutrition and Health, Freshwater Fisheries Research Center, Chinese Academy of Fishery Science, Wuxi 214081, China.
Nanjing Agricultural University · CN

Funding

Central Public-interest Scientific Institution Basal Research Fund, CAFS 2020TD59Modern Agriculture Industrial Technology System of MOF and MARA CARS-45National Natural Science Foundation of China 32172990Project of National Key R&D Program of China 2019YFD0900200
6 · The paper itself

Abstract

Dietary oxidized lipids are key perpetrator to accumulate excessive reactive oxygen species (ROS) that induce oxidative stress for animals. Immoderate oxidative stress dysregulates cell fate, perturbs cellular homeostasis, thereby interrupts metabolism and normal growth. Therefore, a 12-week feeding trial with fish oil (FO, control group), oxidized fish oil (OF), and emodin-supplemented (OF+E) diets was conducted to evaluate the therapeutic mechanism of emodin on metabolic and oxidative resistance in

Indexed as

antioxidantemodinMegalobrama amblycephalametabolismNotch-Nrf2 crosstalkoxidative stress

Identifiers

PMID35740076
PMCPMC9219933
OpenAlexW4282967552

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.