Evidence map›Paper›PMID 35740038›Full record

ArticleAntioxidants (Basel, Switzerland)2022

Diabetes Aggravates Photoreceptor Pathologies in a Mouse Model for Ocular Vitamin A Deficiency.

Srinivasagan Ramkumar, Vipul M Parmar, Jean Moon, Chieh Lee, Patricia R Taylor, Johannes von Lintig

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Srinivasagan RamkumarDepartment of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0002-2542-1501
Vipul M ParmarDepartment of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0001-6696-357X
Jean MoonDepartment of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Chieh LeeDepartment of Ophthalmology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Patricia R TaylorDepartment of Ophthalmology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Johannes von LintigDepartment of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0002-2079-2143
Case Western Reserve University · US

Funding

TISSUE CULTURE AND HYBRIDOMA MODULEP30EY011373 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI Irina A Pikuleva · 1997 to 2026
$17.7M
VISUAL SCIENCES TRAINING PROGRAMT32EY007157 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI Johannes Friedrich von Lintig · 2000 to 2026
$5.5M
STRA6 and Ocular Vitamin A HomeostasisR01EY028121 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI Johannes Friedrich von Lintig · 2018 to 2026
$4.3M
PREDOCTORAL TRAINING PROGRAM IN MOLECULAR THERAPEUTICST32GM008803 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI MIEYAL, JOHN J, NIEMAN, MARVIN THOMAS · 2001 to 2023
$4.2M
Identification of Immunomodulators for Diabetic Retinopathy TherapeuticsR01EY030487 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI TAYLOR, PATRICIA R · 2020 to 2024
$2.0M
The role of IL-17A in the onset and progression of diabetic retinopathy in VA patientsI01CX002204 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI TAYLOR, PATRICIA R · 2021 to 2024
–
CSRD VA I01 CX002204NEI NIH HHS EY028121, EY030487,EY007157,EY011373NEI NIH HHS P30 EY011373NEI NIH HHS R01 EY028121NEI NIH HHS R01 EY030487NEI NIH HHS T32 EY007157NIGMS NIH HHS T32 GM008803
6 · The paper itself

Abstract

Emerging evidence indicates that diabetes disturbs photoreceptor function and vitamin A homeostasis. However, the biochemical basis of this phenotype is not well established. Here, we compared the effects of streptozotocin-induced diabetes in wild-type (WT) mice and

Indexed as

diabetesoxidative stressphotoreceptorsStra6vitamin A homeostasis

Identifiers

PMID35740038
PMCPMC9219864
OpenAlexW4281723710

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.