Evidence map›Paper›PMID 35740036›Full record

ArticleAntioxidants (Basel, Switzerland)2022

Soluble Free, Esterified and Insoluble-Bound Phenolic Antioxidants from Chickpeas Prevent Cytotoxicity in Human Hepatoma HuH-7 Cells Induced by Peroxyl Radicals.

Adriano Costa de Camargo, Alina Concepción Alvarez, María Fernanda Arias-Santé, Juan Esteban Oyarzún, Marcelo E Andia, Sergio Uribe, Paula Núñez Pizarro, Simón M Bustos, Andrés R Schwember, Fereidoon Shahidi and 1 more

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Exudate and Propolis fromPlants (Basel, Switzerland) · 2024
    Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Adriano Costa de CamargoNutrition and Food Technology Institute, University of Chile, Santiago 7830490, Chile.ORCID 0000-0001-9404-1193
Alina Concepción AlvarezNutrition and Food Technology Institute, University of Chile, Santiago 7830490, Chile.ORCID 0000-0001-6161-5998
María Fernanda Arias-SantéNutrition and Food Technology Institute, University of Chile, Santiago 7830490, Chile.
Juan Esteban OyarzúnBiomedical Imaging Center, School of Medicine, Pontificia Universidad Católica de Chile, ANID-Millennium Institute for Intelligent Healthcare Engineering-iHEALTH, Santiago 7820436, Chile.
Marcelo E AndiaBiomedical Imaging Center, School of Medicine, Pontificia Universidad Católica de Chile, ANID-Millennium Institute for Intelligent Healthcare Engineering-iHEALTH, Santiago 7820436, Chile.ORCID 0000-0002-1251-5832
Sergio UribeBiomedical Imaging Center, School of Medicine, Pontificia Universidad Católica de Chile, ANID-Millennium Institute for Intelligent Healthcare Engineering-iHEALTH, Santiago 7820436, Chile.
Paula Núñez PizarroDepartamento de Ciencias Vegetales, Facultad de Agronomía e Ingeniería Forestal, Pontificia Universidad Católica de Chile, Santiago 7820436, Chile.ORCID 0000-0002-0230-8231
Simón M BustosDepartamento de Ciencias Vegetales, Facultad de Agronomía e Ingeniería Forestal, Pontificia Universidad Católica de Chile, Santiago 7820436, Chile.
Andrés R SchwemberDepartamento de Ciencias Vegetales, Facultad de Agronomía e Ingeniería Forestal, Pontificia Universidad Católica de Chile, Santiago 7820436, Chile.
Fereidoon ShahidiDepartment of Biochemistry, Memorial University of Newfoundland, St. John's, NL A1C 5S7, Canada.ORCID 0000-0002-9912-0330
Raquel BridiDepartamento de Química Farmacológica y Toxicológica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago 8380000, Chile.
Pontificia Universidad Católica de Chile · CLUniversity of Chile · CLMemorial University of Newfoundland · CA

Funding

Agencia Nacional de Investigación y Desarrollo 1220922Agencia Nacional de Investigación y Desarrollo 3180432Agencia Nacional de Investigación y Desarrollo ICN2021_004Vicerrectoría de Investigación y Desarrollo de la Universidad de Chile UI-005/20
6 · The paper itself

Abstract

Chickpeas are rich sources of bioactive compounds such as phenolic acids, flavonoids, and isoflavonoids. However, the contribution of insoluble-bound phenolics to their antioxidant properties remains unclear. Four varieties of chickpeas were evaluated for the presence of soluble (free and esterified) and insoluble-bound phenolics as well as their antiradical activity, reducing power and inhibition of peroxyl-induced cytotoxicity in human HuH-7 cells. In general, the insoluble-bound fraction showed a higher total phenolic content. Phenolic acids, flavonoids, and isoflavonoids were identified and quantified by UPLC-MS/MS. Taxifolin was identified for the first time in chickpeas. However,

Indexed as

antiradical activityCicer arietinum L.flavonoidshepatoprotectionphenolic acidsreducing power

Identifiers

PMID35740036
PMCPMC9219979
OpenAlexW4281906936

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.