ArticleAntioxidants (Basel, Switzerland)2022
Biological Evaluation of Avocado Residues as a Potential Source of Bioactive Compounds.
Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
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- Optimization of Extraction Parameters for Phenolics Recovery from Avocado Peels Using Ultrasound and Microwave Technologies.Foods (Basel, Switzerland) · 2025Article
- Article
- Effects of Dietary Inclusion of Avocado Seeds on Performance, Nutrient Digestibility, Plasma Biochemical Profile, and Carcass and Meat Traits of Growing Pigs.Animals : an open access journal from MDPI · 2025Article
- In Vitro Antioxidant, Antithrombotic and Anti-Inflammatory Activities of the Amphiphilic Bioactives Extracted from Avocado and Its By-Products.Antioxidants (Basel, Switzerland) · 2025Article
- Oxidative Stability of Virgin Avocado Oil Enriched with Avocado Leaves and Olive-Fruit-Processing By-Products (Leaves, Pomace) via Ultrasound-Assisted Maceration.Foods (Basel, Switzerland) · 2025Article
- Functional compounds in tropical fruit processing by-products and intrinsic factors affecting their composition: A review.Current research in food science · 2025Review
- Avocado (Frontiers in nutrition · 2025Review
- Towards Characterization of Hass Avocado Peel and Pulp Proteome during Postharvest Shelf Life.Proteomes · 2024Article
- Zwitterion-Lubricated Hydrogel Microspheres Encapsulated with Metformin Ameliorate Age-Associated Osteoarthritis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- The Nutritional Potential of Avocado By-Products: A Focus on Fatty Acid Content and Drying Processes.Foods (Basel, Switzerland) · 2024Article
- Effects of Delaying the Storage of 'Hass' Avocados under a Controlled Atmosphere on Skin Color, Bioactive Compounds and Antioxidant Capacity.Plants (Basel, Switzerland) · 2024Article
- Evaluation of Bioactive Effects of Five Plant Extracts with Different Phenolic Compositions against Different Therapeutic Targets.Antioxidants (Basel, Switzerland) · 2024Article
- The Potential ofAntioxidants (Basel, Switzerland) · 2023Article
- Study of Influence of Extraction Method on the Recovery Bioactive Compounds from Peel Avocado.Molecules (Basel, Switzerland) · 2023Article
- Enzymatic, Antioxidant, and Antimicrobial Activities of Bioactive Compounds from Avocado (Plants (Basel, Switzerland) · 2023Article
- Agri-Food Wastes as Natural Source of Bioactive Antioxidants.Antioxidants (Basel, Switzerland) · 2023Article
- Impact of Lactic Acid Bacteria Fermentation on Phenolic Compounds and Antioxidant Activity of Avocado Leaf Extracts.Antioxidants (Basel, Switzerland) · 2023Article
- Bioactivity and Component Analysis of Water Extract ofFoods (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Avocado seed and peel are the main by-products from avocado industrialisation, and account for nearly 30% of fruit weight. Although they are usually discarded, their high phenolic content has been deeply associated with several nutritional and functional benefits. Thus, for a comprehensive analytical evaluation of both semi-industrial extracts, various steps have been developed: tentative characterisation and quantification of the phenolic composition using HPLC-ESI-qTOF-MS, determination of TPC and antioxidant activity by Folin-Ciocalteu, FRAP, TEAC and ORAC methods, evaluation of scavenging capacity against different ROS and measurement of the enzymatic inhibitory potential against potentially harmful enzymes. Finally, their bioactive potential was tested in a human platelet model where antiaggregatory activity was measured. Hence, 48 different compounds were identified, where flavonoids and procyanidins were the most representative groups. The higher TPC was found in avocado peel extract (190 ± 3 mg/g), which showed more antioxidant power and more capacity to decrease ROS generation than seed extract (60 ± 2 mg/g). In addition, both extracts showed enzymatic inhibition, especially against hyaluronidase, xanthine oxidase and acetylcholinesterase. Lastly, avocado peel was proven to inhibit platelet aggregation with significant results at 1, 0.75 and 0.5 mg/mL, where the extract showed reducing effects on agonists' expression such as p-selectin or GPIIb/IIIa complex. These results demonstrate that both semi-industrial extracts-above all, avocado peel-have an interesting potential to be exploited as a natural by-product with antioxidant properties with multiple applications for the prevention of different pathologies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.