ArticleAnimals : an open access journal from MDPI2022
Determination of the Optimal Level of Dietary Zinc for Newly Weaned Pigs: A Dose-Response Study.
Article in Animals : an open access journal from MDPI, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Bis-glycinate bound zinc supplementation in sows modulates sows and piglets gut microbiota and reduces piglet diarrhea incidence.Scientific reports · 2026Article
- Replacement of added trace minerals (zinc, copper, iron, and manganese) by a consensus bacterial 6-phytase variant in weaned pigs fed an all-vegetable diet.Journal of animal science · 2026Article
- Effects of different combinations of dietary zinc and copper levels on the mitochondrial energy metabolism, oxidative balance, antioxidant system, and inflammation in weaned pigs.Journal of animal science · 2026Article
- The Antagonistic Influence of Phytic Acid on Zinc Absorption: AnNutrients · 2025Article
- Integrated faecal microbiota and blood metabolic changes following different dietary zinc oxide levels in weaned piglets.Scientific reports · 2025Article
- The use of silver nanoparticles in pigs - An invited review.Veterinarni medicina · 2025Review
- Deletion of metal transporter Zip14 reduces major histocompatibility complex II expression in murine small intestinal epithelial cells.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A comparison of feeding acetylated high-amylose maize starch and zinc oxide in weaned pigs experimentally inoculated with an enterotoxigenic strain of Escherichia coli.Journal of animal science · 2025Article
- Impact of zinc oxide on gut health, immunity, and growth in weaned piglets: exploring potential modes of action.Frontiers in veterinary science · 2025Article
- Effects of replacing zinc oxide with different levels of zinc lactate on growth performance, serum indexes, intestinal health and gut microbiota in weaned piglets.Frontiers in microbiology · 2025Review
- The Mechanism of Zinc Oxide in Alleviating Diarrhea in Piglets after Weaning: A Review from the Perspective of Intestinal Barrier Function.International journal of molecular sciences · 2024Review
- Zinc status and indicators of intestinal health in enterotoxigenic Escherichia coli F18 challenged newly weaned pigs fed diets with different levels of zinc.Journal of animal science · 2024Article
- Exploring zinc deficiency using serum Zn levels: consequences and potential solutions in suckling pigs.Journal of animal science · 2024Article
- Determination of the optimal dietary zinc content for pigs between 10 and 30 kg body weight.Journal of animal science · 2023Article
- Effects of dietary zinc/copper ratios on the metabolism of zinc and copper in weaned pigs.Journal of animal science · 2023Article
- Effects of Protein-Chelated Zinc Combined with Mannan-Rich Fraction to Replace High-Dose Zinc Oxide on Growth Performance, Nutrient Digestibility, and Intestinal Health in Weaned Piglets.Animals : an open access journal from MDPI · 2022Article
- Too Much of a Good Thing: Rethinking Feed Formulation and Feeding Practices for Zinc in Swine Diets to Achieve One Health and Environmental Sustainability.Animals : an open access journal from MDPI · 2022Review
- Bioavailability of Different Zinc Sources in Pigs 0-3 Weeks Post-Weaning.Animals : an open access journal from MDPI · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
One hundred and eighty individually housed piglets with an initial body weight of 7.63 ± 0.98 kg (at 28 days of age) were fed a diet containing either 153, 493, 1022, 1601, 2052 or 2407 mg zinc/kg (added Zn as zinc oxide; ZnO) from day 0-21 post weaning to determine the optimal level of Zn for weaned piglets. Body weight, feed intake and faecal scores were recorded, and blood and faecal samples were collected. Dietary Zn content quadratically affected both feed intake and gain in the first two weeks, with an approximately 1400 mg Zn/kg diet and a Zn intake of 400 mg/day as the optimal levels. The relative risk of diarrhoea increased up to 60% at day 7 and 14 if serum Zn status dropped below the weaning level (767 µg/L), and maintain the weaning serum Zn status required approximately 1100 mg Zn/kg (166 mg Zn/day) during week 1. Blood markers of intestinal integrity (D-lactate and diamine oxidase) were unaffected by dietary Zn, and dietary Zn levels of 1022 and 1601 mg/kg did not affect the faecal numbers of total bacteria, Lactobacilli and E. Coli bacteria compared to 153 mg Zn/kg. These results indicate that the requirement for Zn in newly weaned piglets may be substantially higher than currently assumed.
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