Evidence map›Paper›PMID 35739553›Full record

Trial reportCritical care (London, England)2022

The PROMIZING trial enrollment algorithm for early identification of patients ready for unassisted breathing.

Clement Brault, Jordi Mancebo, Juan-Carlos Suarez Montero, Tracey Bentall, Karen E A Burns, Thomas Piraino, François Lellouche, Pierre-Alexandre Bouchard, Emmanuel Charbonney, Guillaume Carteaux and 9 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Critical care (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06040138 (Monitoring of Breathing Effort Through Pressure Time Product Measurement Using Airway Occlusion Pressure), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06040138 unknown statusnot on this mapstarted 2023, after this paper: background citation

Monitoring of Breathing Effort Through Pressure Time Product Measurement Using Airway Occlusion Pressure

TypeobservationalSponsorHospital Italiano de Buenos AiresRan2023 to 2024Enrolled50ConditionsRespiratory Failure, Weaning FailureArmsEnd expiratory occlusion maneuver
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 10 institutions in 3 countries.

Clement BraultKeenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, 209 Victoria St, Toronto, ON, Canada. Clement.brault@unityhealth.to.
Jordi ManceboIntensive Care Department, Hospital Universitari de La Santa Creu I Sant Pau, Barcelona, Spain.
Juan-Carlos Suarez MonteroIntensive Care Department, Hospital Universitari de La Santa Creu I Sant Pau, Barcelona, Spain.
Tracey BentallInterdepartmental Division of Critical Care, University of Toronto, Toronto, Canada.
Karen E A BurnsInterdepartmental Division of Critical Care, University of Toronto, Toronto, Canada.
Thomas PirainoUnity Health Toronto - St. Michael's Hospital, Toronto, ON, Canada.
François LelloucheDépartement de Médecine Québec, Université Laval, Québec City, QC, Canada.
Pierre-Alexandre BouchardInstitut Universitaire de Cardiologie Et de Pneumologie de Québec, Québec City, QC, Canada.
Emmanuel CharbonneyCentre de Recherche du Centre Hospitalier de L'Université de Montréal, Montréal, QC, Canada.
Guillaume CarteauxMedical Intensive Care Department, AP-HP, Henri Mondor University Hospital, Créteil, France.
Tommaso MaraffiService de Réanimation, Centre Hospitalier Intercommunal de Créteil, 40 Avenue de Verdun, 94000, Créteil, France.
Gaëtan BeduneauUNIROUEN, EA 3830, Medical Intensive Care Unit, Rouen University Hospital, Normandie University, 76000, Rouen, France.
Alain MercatMedical Intensive Care Unit, Angers University Hospital, Angers, France.
Yoanna SkrobikOpus Clinic, Montreal, QC, Canada.
Fei ZuoUnity Health Toronto - St. Michael's Hospital, Toronto, ON, Canada.
Myriam Lafreniere-RoulaApplied Health Research Centre, Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, ON, Canada.
Kevin ThorpeDalla Lana School of Public Health, University of Toronto and Applied Health Research Centre, Toronto, ON, Canada.
Laurent Brochard *Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, 209 Victoria St, Toronto, ON, Canada.
Karen J Bosma *London Health Sciences Centre, University of Western Ontario, London, ON, Canada.
St. Michael's Hospital · CAHospital de Sant Pau · ESInstitut universitaire de cardiologie et de pneumologie de Québec · CAUniversity of Toronto · CACentre Hospitalier de l’Université de Montréal · CAHôpital Intercommunal de Créteil · FRInserm · FRNormandie Université · FRUniversité d'Angers · FRWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLiberating patients from mechanical ventilation (MV) requires a systematic approach. In the context of a clinical trial, we developed a simple algorithm to identify patients who tolerate assisted ventilation but still require ongoing MV to be randomized. We report on the use of this algorithm to screen potential trial participants for enrollment and subsequent randomization in the Proportional Assist Ventilation for Minimizing the Duration of MV (PROMIZING) study.

methodsThe algorithm included five steps: enrollment criteria, pressure support ventilation (PSV) tolerance trial, weaning criteria, continuous positive airway pressure (CPAP) tolerance trial (0 cmH

resultsAmong the 374 enrolled patients, 93 (25%) patients passed all five steps. At time of enrollment, most patients were on PSV (87%) with a mean (± standard deviation) F

conclusionThe trial algorithm permitted identification of 93 (25%) patients who were ready to extubate, while their clinicians predicted a duration of ventilation higher than 24 h.

Indexed as

Airway ExtubationVentilator WeaningAlgorithmsHumansOxygenPositive-Pressure RespirationRespiration, ArtificialOxygenCritical careExtubationMechanical ventilationRespiratory mechanicsVentilator weaning

Identifiers

PMID35739553
PMCPMC9219177
OpenAlexW4283321861

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.