Evidence map›Paper›PMID 35739527›Full record

ArticleJournal of translational medicine2022

Exosome-mediated lncRNA SND1-IT1 from gastric cancer cells enhances malignant transformation of gastric mucosa cells via up-regulating SNAIL1.

Guohua Jin, Jianguang Zhang, Tingting Cao, Bang Chen, Yu Tian, Yang Shi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Guohua JinDepartment of Gastric & Intestine, The First Hospital of Jilin University, No.1 Xinmin Street, Changchun, 130021, Jilin, China.ORCID 0000-0002-0034-7819
Jianguang ZhangDepartment of Gastric & Intestine, The First Hospital of Jilin University, No.1 Xinmin Street, Changchun, 130021, Jilin, China.
Tingting CaoDepartment of Gastric & Intestine, The First Hospital of Jilin University, No.1 Xinmin Street, Changchun, 130021, Jilin, China.
Bang ChenDepartment of Gastric & Intestine, The First Hospital of Jilin University, No.1 Xinmin Street, Changchun, 130021, Jilin, China.
Yu TianDepartment of Gastroenterology, The Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, 830002, Xinjiang, China.
Yang ShiDepartment of Gastric & Intestine, The First Hospital of Jilin University, No.1 Xinmin Street, Changchun, 130021, Jilin, China. shiyang@jlu.edu.cn.
Jilin University · CNXinjiang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastric cancer (GC), as one of the most common malignancies across the globe, is the fourth leading cause of cancer-related deaths. Though a large body of research has been conducted to develop the therapeutic methods of GC, the survival rate of advanced patients is still poor. We aimed to dig into the potential regulatory mechanism of GC progression.

methodsBioinformatics tools and fundamental assays were performed at first to confirm the candidate genes in our study. The functional assays and mechanism experiments were conducted to verify the regulatory mechanisms of the genes underlying GC progression.

resultsLong non-coding RNA (lncRNA) SND1 intronic transcript 1 (SND1-IT1) is highly expressed in exosomes secreted by GC cells. SND1-IT1 was verified to bind to microRNA-1245b-5p (miR-1245b-5p) through competitive adsorption to promote ubiquitin specific protease 3 (USP3) messenger RNA (mRNA) expression. SND1-IT1 was validated to recruit DEAD-box helicase 54 (DDX54) to promote USP3 mRNA stability. SND1-IT1 induces malignant transformation of GES-1 cells through USP3. USP3 mediates the deubiquitination of snail family transcriptional repressor 1 (SNAIL1).

conclusionsExosome-mediated lncRNA SND1-IT1 from GC cells enhances malignant transformation of GES-1 cells via up-regulating SNAIL1.

Indexed as

ExosomesRNA, Long NoncodingSnail Family Transcription FactorsStomach NeoplasmsCell Line, TumorCell MovementCell ProliferationDEAD-box RNA HelicasesEndonucleasesGastric MucosaGene Expression Regulation, NeoplasticHumansNeoplasm InvasivenessNeoplasm ProteinsUbiquitin-Specific ProteasesDDX54 protein, humanDEAD-box RNA HelicasesEndonucleasesNeoplasm ProteinsRNA, Long NoncodingSNAI1 protein, humanSnail Family Transcription FactorsSND1 protein, humanUbiquitin-Specific ProteasesUSP3 protein, humanDeubiquitinationExosomeGastric cancerSND1-IT1USP3

Identifiers

PMID35739527
PMCPMC9229915
OpenAlexW4283325038

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.