Evidence map›Paper›PMID 35739412›Full record

ReviewAdvances in experimental medicine and biology2023

Mitochondrial Permeability Transition in Stem Cells, Development, and Disease.

Sandeep P Dumbali, Pamela L Wenzel

Open access · greenAbstract readReview
In one paragraph

Review in Advances in experimental medicine and biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sandeep P DumbaliDepartment of Integrative Biology & Pharmacology, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Pamela L WenzelDepartment of Integrative Biology & Pharmacology, The University of Texas Health Science Center at Houston, Houston, TX, USA. Pamela.L.Wenzel@uth.tmc.edu.
The University of Texas Health Science Center at Houston · US

Funding

Biomechanical Determinants of Hematopoietic Stem Cell PotentialR01DK111599 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI PAMELA LYNN WENZEL · 2018 to 2026
$4.2M
NIDDK NIH HHS R01 DK111599
6 · The paper itself

Abstract

The mitochondrial permeability transition (mPT) is a process that permits rapid exchange of small molecules across the inner mitochondrial membrane (IMM) and thus plays a vital role in mitochondrial function and cellular signaling. Formation of the pore that mediates this flux is well-documented in injury and disease but its regulation has also emerged as critical to the fate of stem cells during embryonic development. The precise molecular composition of the mPTP has been enigmatic, with far more genetic studies eliminating molecular candidates than confirming them. Rigorous studies in the recent decade have implicated central involvement of the F

Indexed as

Mitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PoreAdenosine TriphosphateCalciumMitochondrial Transmembrane Permeability-Driven NecrosisPermeabilityStem CellsAdenosine TriphosphateCalciumMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PoreAdenine nucleotide translocatorATP synthaseCalcium signalingCyclophilin DCyclosporin ADifferentiationMitochondrial permeability transition poreNIM811Oxidative phosphorylationReactive oxygen speciesStem cells

Identifiers

PMID35739412
PMCPMC12951221
OpenAlexW4283462487

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.