ArticleNature metabolism2022
Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited.
Open access · greenAbstract read
In one paragraph
Article in Nature metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 78 citations in OpenAlex.
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- Drugging small-molecule compounds in autophagy-dependent cell death to overcome cancer therapy resistance.Apoptosis : an international journal on programmed cell death · 2026Review
- Fatty Acid Metabolism and Hypoxia in the Tumor Microenvironment: Metabolic Adaptation and Clinical Potential in Colorectal Cancer.Biomedicines · 2026Review
- Loss of ATP-Dependent Citrate Lyase Drives Left Ventricular Dysfunction by Metabolic Remodeling.Circulation · 2026Article
- Overexpression of NMNAT3 suppresses melanoma progression by reprogramming NAD⁺ metabolism.Translational oncology · 2026Article
- L-type calcium channel-mediated lipid metabolic reprogramming in gastric adenocarcinoma progression.Translational oncology · 2026Article
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- Shaping death: how the microbiome regulates tumour cell demise and therapy response.Cancer metastasis reviews · 2026Review
- A genetically encoded bifunctional enzyme mitigates redox imbalance and lipotoxicity.Nature metabolism · 2026Article
- A gene signature associated with alpha-linolenic acid metabolism predicts clinical prognosis in hepatocellular carcinoma.European journal of medical research · 2026Article
- Short-chain fatty acids in the tumor microenvironment: from molecular mechanisms to cancer therapy.Theranostics · 2026Review
- Collateral metabolic vulnerabilities unveiled by loss of isozyme diversity in breast cancer.Genome medicine · 2025Article
- Tumor-stromal metabolic crosstalk in pancreatic cancer.Trends in cell biology · 2025Review
- circRNA-02213 Regulates Milk Fat Synthesis in Bovine Mammary Epithelial Cells via ACSS2.Genes · 2025Article
- The integral membrane protein smim4 modulates redox balance via malate compartmentalization in pancreatic cancer.Nature communications · 2025Article
- Fructose and glucose from sugary drinks enhance colorectal cancer metastasis via SORD.Nature metabolism · 2025Article
- An alternative route for β-hydroxybutyrate metabolism supports cytosolic acetyl-CoA synthesis in cancer cells.Nature metabolism · 2025Article
- Early adipose tissue wasting in a preclinical model of human lung cancer cachexia.Cell reports · 2025Article
- Cancer cells differentially modulate mitochondrial respiration to alter redox state and enable biomass synthesis in nutrient-limited environments.bioRxiv : the preprint server for biology · 2025Article
- Adaptation mechanisms in cancer: Lipid metabolism under hypoxia and nutrient deprivation as a target for novel therapeutic strategies (Review).Molecular medicine reports · 2025Review
Corrections and comments
- Commented on byNAD2022
Authors and funding
13 authors at 8 institutions in 1 country.
Zhaoqi Li *Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Brian W Ji *Department of Systems Biology, Columbia University, New York, NY, USA.
Purushottam D Dixit *Department of Systems Biology, Columbia University, New York, NY, USA.
Konstantine TchourineDepartment of Systems Biology, Columbia University, New York, NY, USA.
Evan C LienKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Aaron M HosiosKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Keene L AbbottKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-6166-704X
Justine C RutterKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Anna M WestermarkKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Elizabeth F GorodetskyKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Lucas B SullivanKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-6745-8222
Matthew G Vander HeidenKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. mvh@mit.edu.ORCID http://orcid.org/0000-0002-6702-4192
Dennis VitkupDepartment of Systems Biology, Columbia University, New York, NY, USA. dv2121@cumc.columbia.edu.ORCID http://orcid.org/0000-0003-4259-8162
Massachusetts Institute of Technology · USColumbia University · USColumbia University Irving Medical Center · USDana-Farber Cancer Institute · USFred Hutch Cancer Center · USHarvard–MIT Division of Health Sciences and Technology · USUniversity of California San Diego · USUniversity of Florida Health · US
Funding
VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MATTHEW G. VANDER HEIDEN · 1985 to 2026
$93.9MMedical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0MPRE-DOCTORAL TRAINING IN THE BIOLOGICAL SCIENCEST32GM007287 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BELL, STEPHEN P., KEATING, AMY E · 1985 to 2019
$40.8MNation Center: Multi-Scale Study- Cellular Networks(RMI)U54CA121852 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CALIFANO, ANDREA · 2005 to 2015
$37.4MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007367 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI REINER, STEVEN L · 1985 to 2021
$25.1MSystematic pharmacological targeting of the core mechanisms responsible for maintaining cancer cell stateU54CA209997 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CALIFANO, ANDREA, HONIG, BARRY H · 2016 to 2021
$10.9MUnderstanding the role of metabolism in cancerR35CA242379 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI VANDER HEIDEN, MATTHEW G. · 2019 to 2025
$5.8MAnalysis of cancer cell metabolism in diverse environmental conditionsR01CA201276 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI VANDER HEIDEN, MATTHEW G., VITKUP, DENNIS · 2016 to 2020
$3.0MSystems Biology of Protein and Phenotypic EvolutionR35GM131884 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI VITKUP, DENNIS · 2019 to 2023
$2.2MMetabolic Constraints on Cancer Cell ProliferationR00CA218679 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI SULLIVAN, LUCAS BRYAN · 2019 to 2021
$863kMetabolic Constraints on Cancer Cell ProliferationK99CA218679 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SULLIVAN, LUCAS BRYAN · 2018 to 2018
$127kHoward Hughes Medical InstituteNCI NIH HHS K99 CA218679NCI NIH HHS P30 CA014051NCI NIH HHS R00 CA218679NCI NIH HHS R01 CA201276NCI NIH HHS R35 CA242379NCI NIH HHS U54 CA121852NCI NIH HHS U54 CA209997NIGMS NIH HHS R35 GM131884NIGMS NIH HHS T32 GM007287NIGMS NIH HHS T32 GM007367NIGMS NIH HHS T32 GM007753
Abstract
Production of oxidized biomass, which requires regeneration of the cofactor NAD
Indexed as
NADNeoplasmsCell ProliferationElectronsHumansHypoxiaLipidsLipidsNAD
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.