Evidence map›Paper›PMID 35739203›Full record

ArticleScientific reports2022

Comparison of early and late Pneumocystis jirovecii Pneumonia in kidney transplant patients: the Korean Organ Transplantation Registry (KOTRY) Study.

Gongmyung Lee, Tai Yeon Koo, Hyung Woo Kim, Dong Ryeol Lee, Dong Won Lee, Jieun Oh, Beom Seok Kim, Myoung Soo Kim, Jaeseok Yang, KOTRY Study Group

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Low-Dose Sulfamethoxazole-Trimethoprim Could PreventTherapeutics and clinical risk management · 2025
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  6. Kidney medicine · 2024
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  7. Review
  8. CMV Infection and Lymphopenia: Warning Markers ofTransplant international : official journal of the European Society for Organ Transplantation · 2024
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 20 institutions in 1 country.

Gongmyung LeeDivision of Nephrology, Department of Internal Medicine, Yonsei University College of Medicine, Severance Hospital, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Tai Yeon KooDivision of Nephrology, Department of Internal Medicine, Korea University Anam Hospital, Seoul, Republic of Korea.
Hyung Woo KimDivision of Nephrology, Department of Internal Medicine, Yonsei University College of Medicine, Severance Hospital, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Dong Ryeol LeeDepartment of Internal Medicine, Maryknoll Medical Center, Pusan, Republic of Korea.
Dong Won LeeDepartment of Internal Medicine, Pusan National University School of Medicine, Pusan, Republic of Korea.
Jieun OhDepartment of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea.
Beom Seok KimDivision of Nephrology, Department of Internal Medicine, Yonsei University College of Medicine, Severance Hospital, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Myoung Soo KimDepartment of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Jaeseok YangDivision of Nephrology, Department of Internal Medicine, Yonsei University College of Medicine, Severance Hospital, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. jcyjs@yuhs.ac.
KOTRY Study Group
Yonsei University · KRMaryknoll Medical Center · KRHallym University · KREwha Womans University · KRKorea University · KRAjou University · KRAsan Medical Center · KRBongSeng Memorial Hospital · KRCHA University Bundang Medical Center · KRChonnam National University · KRChungnam National University Hospital · KREunpyeong Hospital · KRGachon University · KRHanseo University · KRInje University Busan Paik Hospital · KRInje University Ilsan Paik Hospital · KRJeonbuk National University · KRKeimyung University · KRKonkuk University · KRKosin University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Late Pneumocystis jirovecii pneumonia (PJP) is not rare in the era of universal prophylaxis after kidney transplantation. We aimed to determine the nationwide status of PJP prophylaxis in Korea and compare the incidence, risk factors, and outcomes of early and late PJP using data from the Korean Organ Transplantation Registry (KOTRY), a nationwide Korean transplant cohort. We conducted a retrospective analysis using data of 4,839 kidney transplant patients from KOTRY between 2014 and 2018, excluding patients who received multi-organ transplantation or were under 18 years old. Cox regression analysis was performed to determine risk factors for early and late PJP. A total of 50 patients developed PJP. The number of patients who developed PJP was same between onset before 6 months and onsets after 6 months. There were no differences in the rate, duration, or dose of PJP prophylaxis between early and late PJP. Desensitization, higher tacrolimus dose at discharge, and acute rejection were associated with early PJP. In late PJP, old age as well as acute rejection were significant risk factors. In conclusion late PJP is as common and risky as early PJP and requires individualized risk-based prophylaxis, such as prolonged prophylaxis for old patients with a history of rejection.

Indexed as

Kidney TransplantationOrgan TransplantationPneumocystis cariniiPneumonia, PneumocystisAdolescentHumansRegistriesRetrospective Studies

Identifiers

PMID35739203
PMCPMC9226063
OpenAlexW4283320938

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.