Evidence map›Paper›PMID 35739136›Full record

SynthesisScientific reports2022

Long-COVID in children and adolescents: a systematic review and meta-analyses.

Sandra Lopez-Leon, Talia Wegman-Ostrosky, Norma Cipatli Ayuzo Del Valle, Carol Perelman, Rosalinda Sepulveda, Paulina A Rebolledo, Angelica Cuapio, Sonia Villapol

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 272 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
272citing papers in PubMed, 10 pooled it
59.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

272 citing papers in PubMed, 10 syntheses or guidelines pooled it, 496 citations in OpenAlex.

  1. Pooled it
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  4. Neurological manifestations associated with SARS-CoV-2 infection in pediatric patients: a systematic review.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2025
    Pooled it
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  11. Trial
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  15. Article
  16. Neurodegenerative and Cognitive Consequences of Long COVID.International journal of molecular sciences · 2026
    Review
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  19. Review
  20. Observational

212 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 8 institutions in 3 countries.

Sandra Lopez-LeonQuantitative Safety & Epidemiology, Novartis Pharmaceuticals, East Hanover, NJ, USA.ORCID 0000-0001-7504-3441
Talia Wegman-OstroskySubdirección de Investigación básica, Instituto Nacional de Cancerología, Mexico, Mexico.ORCID 0000-0002-3207-6697
Norma Cipatli Ayuzo Del ValleDepartamento de Pediatría, Tecnologico de Monterrey, Monterrey, Mexico.ORCID 0000-0002-8110-3532
Carol PerelmanUniversidad Nacional Autónoma de México (UNAM), SOMEDICyT, RedMPC, Mexico City, Mexico.ORCID 0000-0002-0111-1154
Rosalinda SepulvedaHarvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0003-1146-9552
Paulina A RebolledoDivision of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-9808-063X
Angelica CuapioDepartment of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institute, Stockholm, Sweden.ORCID 0000-0002-9451-1914
Sonia VillapolDepartment of Neurosurgery, Center for Neuroregeneration, Houston Methodist Research Institute, 6670 Bertner Avenue, R10-117, Houston, TX, 77030, USA. svillapol@houstonmethodist.org.ORCID 0000-0002-6174-4113
Emory University · USHarvard University · USHouston Methodist · USInstituto Nacional de Cancerología · MXKarolinska Institutet · SERutgers, The State University of New Jersey · USTecnológico de Monterrey · MXUniversidad Nacional Autónoma de México · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this systematic review and meta-analyses is to estimate the prevalence of long-COVID in children and adolescents and to present the full spectrum of symptoms present after acute COVID-19. We have used PubMed and Embase to identify observational studies published before February 10th, 2022 that included a minimum of 30 patients with ages ranging from 0 to 18 years that met the National Institute for Healthcare Excellence (NICE) definition of long-COVID, which consists of both ongoing (4 to 12 weeks) and post-COVID-19 (≥ 12 weeks) symptoms. Random-effects meta-analyses were performed using the MetaXL software to estimate the pooled prevalence with a 95% confidence interval (CI). Heterogeneity was assessed using I

Indexed as

AgeusiaCOVID-19AdolescentChildChild, PreschoolHumansInfantInfant, NewbornPost-Acute COVID-19 SyndromePrevalenceSARS-CoV-2

Identifiers

PMID35739136
PMCPMC9226045
OpenAlexW4283324651

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.