Evidence map›Paper›PMID 35738905›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2023

Thuc M Le, Hailey R Lee, Evan R Abt, Khalid Rashid, Amanda L Creech, Keke Liang, Jing Cui, Arthur Cho, Liu Wei, Amanda Labora and 13 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Therapeutic targeting of the cGAS-STING pathway in human disease.The Journal of clinical investigation · 2026
    Review
  2. Development of STING probes and visualization of STING in multiple tumor types.European journal of nuclear medicine and molecular imaging · 2025
    Article
  3. Preclinical Evaluation ofACS pharmacology & translational science · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 5 institutions in 3 countries.

Thuc M LeMolecular and Medical Pharmacology, UCLA, Los Angeles, California.
Hailey R LeeMolecular and Medical Pharmacology, UCLA, Los Angeles, California.
Evan R AbtMolecular and Medical Pharmacology, UCLA, Los Angeles, California.
Khalid RashidMolecular and Medical Pharmacology, UCLA, Los Angeles, California.
Amanda L CreechMolecular and Medical Pharmacology, UCLA, Los Angeles, California.
Keke LiangDepartment of Pancreatic and Thyroidal Surgery, Shengjing Hospital, China Medical University, Shenyang, China.
Jing CuiDepartment of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China.
Arthur ChoDepartment of Nuclear Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Liu WeiMolecular and Medical Pharmacology, UCLA, Los Angeles, California.
Amanda LaboraDepartment of Surgery, UCLA, Los Angeles, California.
Charlotte ChanDepartment of Surgery, UCLA, Los Angeles, California.
Eric SanchezMolecular and Medical Pharmacology, UCLA, Los Angeles, California.
Kriti KritiElucidata Corporation, Cambridge, Massachusetts.
Daniel KarinMolecular and Medical Pharmacology, UCLA, Los Angeles, California.
Luyi LiDepartment of Surgery, UCLA, Los Angeles, California.
Nanping WuDepartment of Surgery, UCLA, Los Angeles, California.
Christine MonaMolecular and Medical Pharmacology, UCLA, Los Angeles, California.
Giuseppe CarlucciMolecular and Medical Pharmacology, UCLA, Los Angeles, California.
Willy HugoDavid Geffen School of Medicine, UCLA, Los Angeles, California.
Ting-Ting WuMolecular and Medical Pharmacology, UCLA, Los Angeles, California.
Timothy R DonahueMolecular and Medical Pharmacology, UCLA, Los Angeles, California.
Johannes CzerninMolecular and Medical Pharmacology, UCLA, Los Angeles, California.
Caius G RaduMolecular and Medical Pharmacology, UCLA, Los Angeles, California; cradu@mednet.ucla.edu.
University of California, Los Angeles · USUCLA Jonsson Comprehensive Cancer CenterChina Medical University · CNWuhan Union Hospital · CNYonsei University · KR

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Robert Damoiseaux · 1985 to 2026
$134.5M
UCLA SPORE in Brain CancerP50CA211015 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yvonne Yu-Hsuan Chen · 2017 to 2026
$25.2M
UCLA Tumor Immunology Training ProgramT32CA009120 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Steven M. Dubinett, MICHAEL A TEITELL · 1985 to 2026
$10.3M
Leveraging Vulnerabilities Induced by STING Activation in Pancreatic CancerR01CA250529 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DONAHUE, TIMOTHY R, RADU, CAIUS GABRIEL · 2021 to 2025
$3.1M
Targeting KRAS and adenosine mediated immunosuppression in pancreatic cancerR01CA260678 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DONAHUE, TIMOTHY R, RADU, CAIUS GABRIEL · 2021 to 2025
$3.0M
Metastatic Clonal Heterogeneity and its Impact on Melanoma Therapeutic ResistanceR01CA236910 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HUGO, WILLY · 2020 to 2024
$2.3M
NCI NIH HHS P30 CA016042NCI NIH HHS P50 CA211015NCI NIH HHS R01 CA236910NCI NIH HHS R01 CA250529NCI NIH HHS R01 CA260678NCI NIH HHS T32 CA009120
6 · The paper itself

Abstract

Stimulator of interferon genes (STING) is a mediator of immune recognition of cytosolic DNA, which plays important roles in cancer, cytotoxic therapies, and infections with certain pathogens. Although pharmacologic STING activation stimulates potent antitumor immune responses in animal models, clinically applicable pharmacodynamic biomarkers that inform of the magnitude, duration, and location of immune activation elicited by systemic STING agonists are yet to be described. We investigated whether systemic STING activation induces metabolic alterations in immune cells that can be visualized by PET imaging.

Indexed as

Fluorodeoxyglucose F18Lymphocyte ActivationAnimalsMaleMiceMice, Inbred C57BLPositron-Emission TomographySignal TransductionFluorodeoxyglucose F1818F-FDG PETimmune activationimmunometabolismlymphocytesSTING agonists

Identifiers

PMID35738905
PMCPMC9841248
OpenAlexW4283318261

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.