Evidence map›Paper›PMID 35738636›Full record

ArticleIn vivo (Athens, Greece)

Pediatric Patients With Sickle Cell Disease at a Public Hospital: Nutrition, Compliance and Early Experience With L-Glutamine Therapy.

Moran Gotesman, Guy Elgar, Laura Hernandez Santiago, Abigail Alvarez, Youngju Pak, Henry J Lin, Joseph L Lasky, Eduard H Panosyan

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Moran GotesmanDivision of Pediatric Hematology-Oncology, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, U.S.A.; moran.gotesman@lundquist.org.
Guy ElgarThe Lundquist Institute for Biomedical Innovation, Torrance, CA, U.S A.
Laura Hernandez SantiagoDavid Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, U.S.A.
Abigail AlvarezDivision of Pediatric Hematology-Oncology, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, U.S.A.
Youngju PakThe Lundquist Institute for Biomedical Innovation, Torrance, CA, U.S A.
Henry J LinDivision of Pediatric Hematology-Oncology, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, U.S.A.
Joseph L LaskyDivision of Pediatric Hematology-Oncology, Cure 4 The Kids Foundation, Las Vegas, NV, U.SA.
Eduard H PanosyanDivision of Pediatric Hematology-Oncology, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, U.S.A.
UCLA Medical Center · USLos Angeles Biomedical Research Institute · USCure 4 The Kids Foundation · USUniversity of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimHydration and hydroxyurea (HU) can modify sickle cell disease (SCD) severity. Optimal nutrition and L-glutamine (Gln) may provide further amelioration. PATIENTS AND

methodsReviews of medical records and nutrition surveys were used to investigate severity of pediatric patients with SCD in relation to nutrition, growth, hematologic parameters, and diseasemodifying agents.

resultsAmong 25 females and 25 males (9.1±7 years), beta-globin genotypes were: HbSS/Sβ°, 60%; HbSC, 32%; HbSβ

conclusionYounger, and well-nourished, well-hydrated patients have a milder clinic course. Disease severity was the worse in undernourished teenagers with suboptimal compliance. L-Glutamine with prealbumin monitoring should be considered for further evaluation in pediatric SCD.

Indexed as

Anemia, Sickle CellAntisickling AgentsGlutamineNutritional StatusPatient ComplianceAdolescentChildFemaleHospitals, PublicHumansHydroxyureaMalePrealbuminAntisickling AgentsGlutamineHydroxyureaPrealbuminL-glutaminenutritionSickle cell disease

Identifiers

PMID35738636
PMCPMC9301392
OpenAlexW4283462762

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.