Evidence map›Paper›PMID 35738614›Full record

ArticleIn vivo (Athens, Greece)

The Role of PPAR-gamma C161T Polymorphism in Colorectal Cancer Susceptibility.

Ozlem Kurnaz-Gomleksiz, Bahar Canbay Torun, Turgay Isbir, Turker Bulut, Necmettin Sokucu, Hulya Yilmaz-Aydogan, Emel Canbay

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Colitis Induces Sex-Specific Intestinal Transcriptomic Responses in Mice.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Ozlem Kurnaz-GomleksizAltınbaş University, Faculty of Medicine, Department of Medical Biology, Istanbul, Turkey.
Bahar Canbay TorunIstinye University, Faculty of Medicine, Department of General Surgery, Istanbul, Turkey.
Turgay IsbirYeditepe University, Department of Molecular Department of Medical Biology, Faculty of Medicine, Yeditepe University, Istanbul, Turkey.
Turker BulutIstanbul University, Istanbul Medical Faculty, Department of General Surgery, Istanbul, Turkey.
Necmettin SokucuIstanbul University, Istanbul Medical Faculty, Department of General Surgery, Istanbul, Turkey.
Hulya Yilmaz-AydoganIstanbul University, Aziz Sancar Institute of Experimental Medicine, Department of Molecular Medicine, Istanbul, Turkey.
Emel CanbayNPO Treatment Center for Peritoneal Disseminated Diseases (NPO HIPEC ISTANBUL), Istanbul, Turkey drecanbay@gmail.com.
Istanbul University · TRAltınbaş University · TRIstinye University · TRYeditepe University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimThis study aimed to determine the role of the peroxisome proliferator-activated receptor-gamma (PPARg) C161T genotype and allele frequencies in predisposition to colorectal cancer (CRC). PATIENTS AND

methodsPPARg C161T (His447His; rs3856806) gene polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism analysis in patients with CRC (n=101) and controls (n=238).

resultsThe T161 allele (CT+TT genotypes) of PPARg C161T polymorphism was associated with CRC development (p<0.001; OR=3.239, 95%CI=1.997-5.252). Subgroup analysis showed that the T161 allele was associated with a 3.056-fold increased risk for colon cancer (CC) (p<0.001; 95%CI=1.709-5.464) and 3.529-fold increased risk for rectal cancer (RC) (p<0.001; 95%C=1.784-6.981). Frequencies of the T161 allele were also higher in total CRC and CC patients with poorly differentiated tumors (p<0.001, c

conclusionPPARg T161 allele carriers have increased risk for developing CRC.

Indexed as

Colorectal NeoplasmsPPAR gammaAllelesCase-Control StudiesGenetic Predisposition to DiseaseGenotypeHumansPolymorphism, Single NucleotidePPAR gammaPPARG protein, humancolorectal cancerPPARg C161T polymorphismTurkish population

Identifiers

PMID35738614
PMCPMC9301400
OpenAlexW4283457452

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.