Evidence map›Paper›PMID 35738595›Full record

ArticleIn vivo (Athens, Greece)

Acute Toxicity in the Rat Lung Induced by Intratracheal Instillation of Glycolic Acid.

Seong Kwang Lim, Haewon Kim, Jean Yoo, Woong Kim, Ilseob Shim, Byung-Il Yoon, Pilje Kim, Ig-Chun Eom

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Seong Kwang LimEnvironmental Health Research Department, National Institute of Environmental Research, Incheon, Republic of Korea.
Haewon KimEnvironmental Health Research Department, National Institute of Environmental Research, Incheon, Republic of Korea.
Jean YooEnvironmental Health Research Department, National Institute of Environmental Research, Incheon, Republic of Korea.
Woong KimEnvironmental Health Research Department, National Institute of Environmental Research, Incheon, Republic of Korea.
Ilseob ShimEnvironmental Health Research Department, National Institute of Environmental Research, Incheon, Republic of Korea.
Byung-Il YoonCollege of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Republic of Korea.
Pilje KimEnvironmental Health Research Department, National Institute of Environmental Research, Incheon, Republic of Korea.
Ig-Chun EomEnvironmental Health Research Department, National Institute of Environmental Research, Incheon, Republic of Korea; lsgwang11@korea.kr.
National Institute of Environmental Research · KRKangwon National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimInhalation toxicity tests of glycolic acid, which is used in many household products, have been reported, but the pulmonary toxicity of glycolic-acid has not been confirmed. Here, the lung damage caused by glycolic acid was investigated in rats. MATERIALS AND

methodsAn intratracheal instillation test was performed with glycolic acid in male rats. Bronchoalveolar lavage fluid (BALF) and histopathological analysis were conducted to identify the pulmonary toxicities.

resultsIntratracheal instillation of glycolic acid caused weight loss in animals and increased the content of lactate dehydrogenase, total protein, polymorphonuclear neutrophils, and inflammatory cytokines in BALF. In addition, pulmonary edema, alveolar/interstitial inflammation, and necrosis and desquamation of bronchial/bronchiolar epithelia were confirmed via histopathological examination.

conclusionExposure to glycolic acid can be harmful and toxic to the lungs.

Indexed as

GlycolatesLungAdministration, InhalationAnimalsBronchoalveolar Lavage FluidMaleRatsGlycolatesglycolic acidGlycolic acidintratracheal instillationlungtoxicity

Identifiers

PMID35738595
PMCPMC9301448
OpenAlexW4283462894

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.