Evidence map›Paper›PMID 35738159›Full record

ArticleJournal of psychiatric research2022

Increased sensitivity of insula to supraliminal faces in adults with histories of mood disorders and self-injury.

Melinda Westlund Schreiner, Alina K Dillahunt, Summer B Frandsen, Sophie R DelDonno, Briana L Schubert, Stephanie L Pocius, Lisanne M Jenkins, Michelle T Kassel, Katie L Bessette, Leah Thomas and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatric research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Melinda Westlund SchreinerDepartment of Psychiatry, Huntsman Mental Health Institute, University of Utah, USA. Electronic address: mindy.westlund.schreiner@utah.edu.
Alina K DillahuntDepartment of Psychiatry, Huntsman Mental Health Institute, University of Utah, USA.
Summer B FrandsenDepartment of Psychiatry, Huntsman Mental Health Institute, University of Utah, USA; Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Department of Neurology, Harvard Medical School, USA.
Sophie R DelDonnoDepartment of Psychiatry, University of Illinois at Chicago, USA.
Briana L SchubertCenter for Marital and Family Studies, University of Denver, USA.
Stephanie L PociusJohns Hopkins Bloomberg School of Public Health, USA.
Lisanne M JenkinsDepartment of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, USA.
Michelle T KasselSan Francisco VA Medical Center, University of California, San Francisco, USA.
Katie L BessetteDepartment of Psychiatry, Huntsman Mental Health Institute, University of Utah, USA; Department of Psychiatry, University of Illinois at Chicago, USA; Department of Psychiatry & Biobehavioral Sciences, University of California at Los Angeles, USA.
Leah ThomasDepartment of Psychiatry, Huntsman Mental Health Institute, University of Utah, USA.
Jonathan P StangeDepartment of Psychology, University of Southern California, USA.
Sheila E CrowellDepartment of Psychology, University of Utah, USA.
Scott A LangeneckerDepartment of Psychiatry, Huntsman Mental Health Institute, University of Utah, USA.

Funding

TRAINING THE SCIENCE OF CHILD MENTAL HEALTH TREATMENTT32MH073517 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUMA JACOB, John C. Piacentini · 2006 to 2026
$5.2M
Dimensional RDoC Modeling across the Range of Negative Mood DysfunctionR01MH101487 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LANGENECKER, SCOTT A · 2013 to 2016
$2.5M
NIMH NIH HHS R01 MH101487NIMH NIH HHS T32 MH073517
6 · The paper itself

Abstract

backgroundMood disorders are associated with neurobiological disruptions in subliminal and supraliminal emotion processing. There may be additional variation based on sex and the presence of self-injurious thoughts and behaviors (SITBs). Examining individuals in remission allows us to understand trait-like emotion processing characteristics that persist in the absence of symptoms. This study investigates neural processing in response to supraliminal and subliminal emotional stimuli based upon mood disorder diagnosis, sex, and SITBs.

methodsSeventy-five participants with a history of any mood disorder (AMD; 52 female) and 27 healthy controls (HC; 14 female) completed a fMRI task presenting subliminal and supraliminal facial stimuli. Within the AMD group, 20 had no history of SITBs, 26 had histories of suicidal ideation only, and 27 had histories of both SI and self-injurious behavior. We examined activation of salience network regions of interest including the amygdala, insula, and subgenual anterior cingulate cortex (sgACC) during the task.

resultsAMD showed greater insula activation in response to happy faces relative to sad faces, which was not seen in the HC group. Males exhibited lower insula activation in response to sad faces relative happy faces, a pattern not seen in females. Individuals with SITBs demonstrated a lack of sgACC blunting during supraliminal versus subliminal trials.

conclusionsWe found different patterns of neural responses related to mood disorder status, sex, and SITBs. Findings highlight the importance of considering heterogeneity within diagnoses and examining neurobiological features in the context of remission.

Indexed as

Mood DisordersSelf-Injurious BehaviorAdultAmygdalaEmotionsFacial ExpressionFemaleHumansMagnetic Resonance ImagingMaleSubliminal StimulationEmotion processingMood disordersNeuroimagingSelf-injurious thoughts and behaviorsSubliminalSupraliminal

Identifiers

PMID35738159
PMCPMC12094170

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.