ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2023
Viral Dynamics of Omicron and Delta Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants With Implications for Timing of Release from Isolation: A Longitudinal Cohort Study.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Duration of SARS-CoV-2 shedding: A systematic review.Journal of global health · 2024Pooled it
- Earlier de-isolation of SARS-CoV-2-infected ICU patients using a novel viability PCR: a prospective cohort study.Microbiology spectrum · 2026Article
- Seeing beyond positivity: computer vision approach to decoding BinaxNOW COVID-19 tests and forecasting negative results.BMC digital health · 2026Article
- Barriers to recruitment of an observational SARS-CoV-2 emergency department cohort at Boston Medical Center.BMC emergency medicine · 2025Observational
- Viral load dynamics in asymptomatic and symptomatic patients during Omicron BA.2 outbreak in Shanghai, China, 2022: A longitudinal cohort study.Virologica Sinica · 2024Article
- Review
- Testing for SARS-CoV-2: lessons learned and current use cases.Clinical microbiology reviews · 2024Review
- A robust web-based tool to predict viral shedding in patients with Omicron SARS-CoV-2 variants.ERJ open research · 2024Article
- Timing and Predictors of Loss of Infectivity Among Healthcare Workers With Mild Primary and Recurrent COVID-19: A Prospective Observational Cohort Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Observational
- The immune landscape and viral shedding of Omicron SARS-CoV-2 variants implicate immune escape.Frontiers in medicine · 2024Article
- Single virus fingerprinting by widefield interferometric defocus-enhanced mid-infrared photothermal microscopy.Nature communications · 2023Article
- Recommendations for SARS-CoV-2 testing and organ procurement from deceased donors in the Republic of Korea.Korean journal of transplantation · 2023Review
- Real-time surveillance of international SARS-CoV-2 prevalence using systematic traveller arrival screening: An observational study.PLoS medicine · 2023Observational
- Daily SARS-CoV-2 Nasal Antigen Tests Miss Infected and Presumably Infectious People Due to Viral Load Differences among Specimen Types.Microbiology spectrum · 2023Article
- Durable reprogramming of neutralizing antibody responses following Omicron breakthrough infection.Science advances · 2023Article
- Comparing SARS-CoV-2 testing positivity rates and COVID-19 impact among different isolation strategies: a rapid systematic review and a modelling study.EClinicalMedicine · 2023Article
- Patient and ward related risk factors in a multi-ward nosocomial outbreak of COVID-19: Outbreak investigation and matched case-control study.Antimicrobial resistance and infection control · 2023Article
- When Should Healthcare Workers With Coronavirus Disease 2019 (COVID-19) Return to Work? An Analysis of Follow-up Antigen Test Results After a Positive COVID Test.Open forum infectious diseases · 2023Article
- Extreme differences in SARS-CoV-2 viral loads among respiratory specimen types during presumed pre-infectious and infectious periods.PNAS nexus · 2023Article
- Persistence of Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant in Children and Utility of Rapid Antigen Testing as an Indicator of Culturable Virus.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
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17 authors.
Funding
Abstract
backgroundIn January 2022, US guidelines shifted to recommend isolation for 5 days from symptom onset, followed by 5 days of mask-wearing. However, viral dynamics and variant and vaccination impact on culture conversion are largely unknown.
methodsWe conducted a longitudinal study on a university campus, collecting daily anterior nasal swabs for at least 10 days for reverse-transcription polymerase chain reaction (RT-PCR) testing and culture, with antigen rapid diagnostic testing (RDT) on a subset. We compared culture positivity beyond day 5, time to culture conversion, and cycle threshold trend when calculated from diagnostic test, from symptom onset, by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant, and by vaccination status. We evaluated sensitivity and specificity of RDT on days 4-6 compared with culture.
resultsAmong 92 SARS-CoV-2 RT-PCR-positive participants, all completed the initial vaccine series; 17 (18.5%) were infected with Delta and 75 (81.5%) with Omicron. Seventeen percent of participants had positive cultures beyond day 5 from symptom onset, with the latest on day 12. There was no difference in time to culture conversion by variant or vaccination status. For 14 substudy participants, sensitivity and specificity of day 4-6 RDT were 100% and 86%, respectively.
conclusionsThe majority of our Delta- and Omicron-infected cohort culture-converted by day 6, with no further impact of booster vaccination on sterilization or cycle threshold decay. We found that rapid antigen testing may provide reassurance of lack of infectiousness, though guidance to mask for days 6-10 is supported by our finding that 17% of participants remained culture-positive after isolation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.