Evidence map›Paper›PMID 35737842›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Latent space of a small genetic network: Geometry of dynamics and information.

Rabea Seyboldt, Juliette Lavoie, Adrien Henry, Jules Vanaret, Mariela D Petkova, Thomas Gregor, Paul François

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Generative epigenetic landscapes map the topology and topography of cell fates.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Deriving a genetic regulatory network from an optimization principle.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Article
  7. Scale invariance in early embryonic development.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rabea SeyboldtPhysics Department, McGill University, Montreal, QC H3A2T8, Canada.
Juliette LavoiePhysics Department, McGill University, Montreal, QC H3A2T8, Canada.ORCID 0000-0002-4708-5182
Adrien HenryPhysics Department, McGill University, Montreal, QC H3A2T8, Canada.ORCID 0000-0002-4048-3241
Jules VanaretPhysics Department, McGill University, Montreal, QC H3A2T8, Canada.
Mariela D PetkovaProgram in Biophysics, Harvard University, Cambridge, MA 02138.
Thomas GregorJoseph Henry Laboratory of Physics, Princeton University, Princeton, NJ 08544.
Paul FrançoisPhysics Department, McGill University, Montreal, QC H3A2T8, Canada.ORCID 0000-0002-2223-839X

Funding

The Biophysical and Molecular Mechanisms of Reliability in DevelopmentR01GM097275 · NIGMS · PRINCETON UNIVERSITY · PI GREGOR, THOMAS · 2011 to 2024
$4.9M
Control of the 4D chromatin landscape underlying gene activity during developmentU01DK127429 · NIDDK · PRINCETON UNIVERSITY · PI GREGOR, THOMAS, LEVINE, MICHAEL STEVEN · 2020 to 2024
$3.2M
Imaging chromosome dynamics and measuring its impact on transcriptional activityU01DA047730 · NIDA · PRINCETON UNIVERSITY · PI GREGOR, THOMAS, LEVINE, MICHAEL STEVEN · 2018 to 2019
$740k
NIDA NIH HHS U01 DA047730NIDDK NIH HHS U01 DK127429NIGMS NIH HHS R01 GM097275
6 · The paper itself

Abstract

The high-dimensional character of most biological systems presents genuine challenges for modeling and prediction. Here we propose a neural network-based approach for dimensionality reduction and analysis of biological gene expression data, using, as a case study, a well-known genetic network in the early

Indexed as

Drosophila ProteinsGene Regulatory NetworksNeural Networks, ComputerAnimalsDrosophilaModels, GeneticDrosophila Proteinsdevelopmental biologydimensionality reductionDrosophila gap genesmachine learningsystems biology

Identifiers

PMID35737842
PMCPMC9245618

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.