Evidence map›Paper›PMID 35737835›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Glycan degradation promotes macroautophagy.

Alice D Baudot, Victoria M-Y Wang, Josh D Leach, Jim O'Prey, Jaclyn S Long, Viola Paulus-Hock, Sergio Lilla, David M Thomson, John Greenhorn, Farah Ghaffar and 7 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Frontiers in genetics · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. A HomozygousGenes · 2023
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Alice D BaudotTumour Cell Death and Autophagy Laboratory, Cancer Research UK Beatson Institute, Glasgow G61 1BD, United Kingdom.
Victoria M-Y WangTumour Cell Death and Autophagy Laboratory, Cancer Research UK Beatson Institute, Glasgow G61 1BD, United Kingdom.ORCID 0000-0002-2657-6118
Josh D LeachTumour Cell Death and Autophagy Laboratory, Cancer Research UK Beatson Institute, Glasgow G61 1BD, United Kingdom.
Jim O'PreyTumour Cell Death and Autophagy Laboratory, Cancer Research UK Beatson Institute, Glasgow G61 1BD, United Kingdom.
Jaclyn S LongTumour Cell Death and Autophagy Laboratory, Cancer Research UK Beatson Institute, Glasgow G61 1BD, United Kingdom.ORCID 0000-0002-6644-542X
Viola Paulus-HockTumour Cell Death and Autophagy Laboratory, Cancer Research UK Beatson Institute, Glasgow G61 1BD, United Kingdom.
Sergio LillaTumour Cell Death and Autophagy Laboratory, Cancer Research UK Beatson Institute, Glasgow G61 1BD, United Kingdom.
David M ThomsonStrathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, Glasgow G4 0RE, United Kingdom.
John GreenhornInstitute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom.
Farah GhaffarTumour Cell Death and Autophagy Laboratory, Cancer Research UK Beatson Institute, Glasgow G61 1BD, United Kingdom.ORCID 0000-0001-6131-2604
Colin NixonTumour Cell Death and Autophagy Laboratory, Cancer Research UK Beatson Institute, Glasgow G61 1BD, United Kingdom.ORCID 0000-0002-8085-2160
Miep H HelfrichInstitute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom.ORCID 0000-0001-5569-591X
Douglas StrathdeeTumour Cell Death and Autophagy Laboratory, Cancer Research UK Beatson Institute, Glasgow G61 1BD, United Kingdom.
Judith PrattStrathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, Glasgow G4 0RE, United Kingdom.ORCID 0000-0002-7371-8465
Francesco MarchesiSchool of Veterinary Medicine, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow G61 1QH, United Kingdom.
Sara ZanivanTumour Cell Death and Autophagy Laboratory, Cancer Research UK Beatson Institute, Glasgow G61 1BD, United Kingdom.
Kevin M RyanTumour Cell Death and Autophagy Laboratory, Cancer Research UK Beatson Institute, Glasgow G61 1BD, United Kingdom.ORCID 0000-0002-1059-9681
Cancer Research UK Scotland Institute · GBUniversity of Aberdeen · GBUniversity of Strathclyde · GBUniversity of Glasgow · GB

Funding

Cancer Research UK 15816Cancer Research UK 29800Wellcome TrustWorldwide Cancer Research 16-1194
6 · The paper itself

Abstract

Macroautophagy promotes cellular homeostasis by delivering cytoplasmic constituents to lysosomes for degradation [Mizushima,

Indexed as

FucosidosisMacroautophagyPolysaccharidesalpha-L-FucosidaseAnimalsLysosomesMicealpha-L-FucosidasePolysaccharidesfucosidosislysosomesmacroautophagyα-l-fucosidase 1

Identifiers

PMID35737835
PMCPMC9245654
OpenAlexW4283317208

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.