ArticleNeuropsychology2022
Physical inactivity links depressive symptoms and cognitive functioning among individuals with Parkinson's disease.
Article in Neuropsychology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- A systematic review of the associations between sedentary behavior, physical inactivity, and non-motor symptoms of Parkinson's disease.PloS one · 2024Pooled it
- The Influence of Motor and Nonmotor Factors on Ambulatory Activity in People With Parkinson Disease.Journal of neurologic physical therapy : JNPT · 2026Article
- Characteristics of the Rest and Activity Patterns in Patients With Mild to Moderate Parkinson's Syndrome.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2025Article
- Trends in parkinson's disease mortality in China from 2004 to 2021: a joinpoint analysis.BMC public health · 2024Article
- Beneficial effects of activity level on striatal binding: Careful replication is required.Parkinsonism & related disorders · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
objectiveParkinson's disease (PD) is a neurodegenerative disorder caused by disruption of dopamine-producing cells. PD is associated with motor symptoms and nonmotor symptoms including depression and cognitive impairment. Past research suggests an association between depression and cognitive impairment in PD. Physical activity may have a therapeutic effect on both depression and cognitive impairment. The present study investigates if physical activity mediates the association between depressive symptoms and cognition in a longitudinal sample of individuals with PD.
methodParticipants include individuals newly diagnosed with PD (
resultsA significant direct effect demonstrated depression was associated with worse global cognitive functioning. Furthermore, there was a significant indirect within-person effect, indicating that physical activity fully mediated the association between depression and cognition. Individuals who became more depressed over time became less physically active and subsequently experienced cognitive decline over the 5-year period.
conclusionsFindings have implications for prognostic detection and/or the role of physical activity interventions to buffer effects of depression on cognitive impairment among individuals diagnosed with PD. Physical interventions may potentially be implemented among depressed persons to preserve cognitive functioning. Worsened depression early during PD may be a risk factor for inactivity and cognitive diminishment. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.