Evidence map›Paper›PMID 35737457›Full record

ArticleJCI insight2022

Age-associated gut microbiota impair hippocampus-dependent memory in a vagus-dependent manner.

Damien Rei, Soham Saha, Marianne Haddad, Anna Haider Rubio, Blanca Liliana Perlaza, Marion Berard, Marie-Noelle Ungeheuer, Harry Sokol, Pierre-Marie Lledo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JCI insight, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 44 citations in OpenAlex.

  1. The neuroimmune system and cognition.Nature immunology · 2026
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  4. Frontiers in microbiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Damien ReiInstitut Pasteur de Paris, Paris Cité University, CNRS UMR 3571, Perception and Memory Unit, Paris, France.
Soham SahaInstitut Pasteur de Paris, Paris Cité University, CNRS UMR 3571, Perception and Memory Unit, Paris, France.
Marianne HaddadInstitut Pasteur de Paris, Paris Cité University, CNRS UMR 3571, Perception and Memory Unit, Paris, France.
Anna Haider RubioInstitut Pasteur de Paris, Paris Cité University, CNRS UMR 3571, Perception and Memory Unit, Paris, France.
Blanca Liliana PerlazaInvestigation and Access to BioResources (ICAReB) Platform, Paris, France.
Marion BerardInstitut Pasteur de Paris, Paris Cité University, DT, Animalerie Centrale, Gnotobiology Center, Paris, France.
Marie-Noelle UngeheuerInvestigation and Access to BioResources (ICAReB) Platform, Paris, France.
Harry SokolSorbonne University, INSERM, Saint-Antoine Research Center, CRSA, AP-HP, Saint Antoine Hospital, Gastroenterology Department, Paris, France.
Pierre-Marie LledoInstitut Pasteur de Paris, Paris Cité University, CNRS UMR 3571, Perception and Memory Unit, Paris, France.
Centre National de la Recherche Scientifique · FRInstitut Icare · CHInserm · FRInstitut Pasteur · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging is known to be associated with hippocampus-dependent memory decline, but the underlying causes of this age-related memory impairment remain highly debated. Here, we show that fecal microbiota transplantation (FMT) from aged, but not young, animal donors into young mice is sufficient to trigger profound hippocampal alterations, including astrogliosis, decreased adult neurogenesis, decreased novelty-induced neuronal activation, and impairment in hippocampus-dependent memory. Furthermore, similar alterations were reported when mice were subjected to an FMT from aged human donors. To decipher the mechanisms involved in mediating these microbiota-induced effects on brain function, we mapped the vagus nerve-related (VN-related) neuronal activity patterns and report that aged FMT animals showed a reduction in neuronal activity in the ascending-VN output brain structure, whether under basal condition or after VN stimulation. Targeted pharmacogenetic manipulation of VN-ascending neurons demonstrated that the decrease in vagal activity is detrimental to hippocampal functions. In contrast, increasing vagal ascending activity alleviated the adverse effects of aged mouse FMT on hippocampal functions and had a promnesic effect in aged mice. Thus, pharmacogenetic VN stimulation is a potential therapeutic strategy to lessen microbiota-dependent age-associated impairments in hippocampal functions.

Indexed as

Gastrointestinal MicrobiomeAdultAgedAnimalsFecal Microbiota TransplantationHippocampusHumansMiceNeurogenesisVagus NerveAgingBehaviorMouse modelsNeuroscience

Identifiers

PMID35737457
PMCPMC9462480
OpenAlexW4283369161

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.