ArticleTranslational vision science & technology2022
Two-Year Choroidal Thickness Attenuation and Its Associations in Healthy Chinese Adults.
Article in Translational vision science & technology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Choroidal vascularity index is independent of ocular and image-based factors in healthy eyes: a systematic review and meta-analysis.Scientific reports · 2025Pooled it
- Thinning Choroidal Thickness and Flattening Morphology of Higher Myopia Eyes in Chinese Adults with Anisometropic Myopia: A Comparative Study.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- New findings on choroidal features in healthy people by ultra-widefield swept-source optical coherence tomography angiography.Scientific reports · 2023Observational
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Identifying clinical associations causing attenuation in choroidal thickness (CT) among healthy Chinese adults. Methods: A 2-year longitudinal study was conducted in volunteers aged over 30 years from China. All participants had no history of eye disease or surgery. All subjects underwent swept-source optical coherence tomography to measure the CT in the macular region at baseline and at 2-year follow-up. The regression models were based on the generalized estimating equation. Results: A total of 603 eyes of 336 healthy participants were included in the final analysis (mean [SD] age, 58.88 [8.82] years; 74.70% female). Mean (SD) choroidal thickness (MCT) was reduced significantly from 206.62 (72.42) to 194.02 (72.08) µm (difference, -12.60 µm; 95% confidence interval [CI], -13.62 to -11.57). Among the Early Treatment of Diabetic Retinopathy Study (ETDRS) grid, CT at the subfoveal sector showed the greatest 2-year reduction (difference, -14.55 µm; 95% CI, -15.87 to -13.22). The largest 2-year change was observed in the 50 to 59 years group (difference, -14.51 µm; 95% CI, -16.71 to -12.32). Multivariate regression showed female gender (β = -2.85; 95% CI, -5.65 to -0.56) and baseline MCT (β = -0.040; 95% CI, -0.056 to -0.024) were significantly and independently associated with greater 2-year CT decrease. Conclusions: These results indicated that CT among Chinese healthy adults decreased during the 2-year follow-up, and the greater choroidal thinning rate was significantly associated with female gender and larger baseline MCT. Translational Relevance: Longitudinal CT data of healthy adults provide a reference range when evaluating pathologic variations, especially for the age-related retinal-choroidal disorders.
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