ReviewPediatric nephrology (Berlin, Germany)2022
Kidney disease and thyroid dysfunction: the chicken or egg problem.
Review in Pediatric nephrology (Berlin, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association between hypothyroidism and risk of chronic kidney disease: evidence from a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Association between hypothyroidism, levothyroxine replacement and kidney function outcomes: a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Correlations Among Glycemia and Glucose Variability, Thyroid Hormones, and Albuminuria in Patients With Type 2 Diabetes Mellitus.The Kaohsiung journal of medical sciences · 2026Article
- Association between thyroid hormone sensitivity indices and renal function in community-dwelling euthyroid older adults: a cross-sectional study.Scientific reports · 2026Article
- Correlation between thyroid function and proteinuria in patients with chronic kidney disease stages 3 and 4.International urology and nephrology · 2025Observational
- The effect of thyroid disorders on the cutaneous manifestations in patients with chronic kidney disease.Renal failure · 2025Review
- Role of subclinical hypothyroidism on kidney damage in children with obesity.International journal of obesity (2005) · 2025Article
- FT4 is a novel indicator for risk assessment of severe hypocalcemia following parathyroidectomy.Journal of endocrinological investigation · 2025Article
- Hypothyroid-induced hyponatraemia in a premature infant with a false-negative newborn screening for congenital hypothyroidism.BMJ case reports · 2025Article
- Optimizing Care for Primary Glomerulonephritis: The Role of Thyroid Evaluation.Endocrine, metabolic & immune disorders drug targets · 2025Observational
- Assessment of Renal Function in Patients with Chronic Kidney Disease with and without Hypothyroidism.Ethiopian journal of health sciences · 2025Article
- Clinical associations with thyroid disease in ANCA-associated vasculitis.Clinical rheumatology · 2024Article
- Relationship of Thyroid Function with Renal Hemodynamics and Cholesterol Metabolism in Proteinuric Kidney Disease: A Pilot Study.Metabolites · 2024Article
- Non-Thyroidal Illness in Chronic Renal Failure: Triiodothyronine Levels and Modulation of Extra-Cellular Superoxide Dismutase (ec-SOD).Antioxidants (Basel, Switzerland) · 2024Article
- Bidirectional negative relationship between thyrotropin and kidney function during alcohol intoxication in males.Frontiers in nephrology · 2024Article
- Uric Acid Metabolic Disorders in Pituitary-Target Gland Axis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Review
- Observational
- Hashimoto's thyroiditis, vitiligo, anemia, pituitary hyperplasia, and lupus nephritis-A case report of autoimmune polyglandular syndrome type III C + D and literature review.Frontiers in pediatrics · 2023Article
- Clinicopathological features and prognosis of idiopathic membranous nephropathy with thyroid dysfunction.Frontiers in endocrinology · 2023Article
- Creatinine and Cystatin C: A Measure of Renal Function in Men With Testosterone-Induced Muscle Hypertrophy.American journal of men's healthArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with non-dialysis-dependant chronic kidney disease (NDD-CKD) and dialysis-dependant chronic kidney disease (DD-CKD) frequently also suffer from thyroid disorders, especially hypothyroidism which is found two to five times more often among them compared to the general population. Emerging research has illustrated the potential prognostic implications of this association as NDD-CKD and DD-CKD patients with hypothyroidism have been shown to have higher mortality rates, and treatment of subclinical hypothyroidism in NDD-CKD patients has been reported to attenuate the decline of glomerular filtration rate over time. This review illustrates the bidirectional, multi-layered interplay between the kidneys and the thyroid gland explaining how pathologies in one organ will affect the other and vice versa. Additionally, it outlines the impact of thyroid disorders on routine parameters of kidney function (especially serum creatinine and serum cystatin C) that nephrologists should be aware of in their clinical practice. Lastly, it summarizes the emerging evidence from clinical studies on how treatment of subclinical hypothyroidism in NDD-CKD and DD-CKD patients may potentially have beneficial effects on kidney function as well as mortality. While most of the research in this area has been performed on adult patients, we specifically discuss what is currently known about thyroid dysfunctions in paediatric CKD patients as well and provide management suggestions. The evidence accumulated so far clearly indicates that further, prospective studies with meticulous methodology are warranted to refine our understanding of thyroid disorders in paediatric and adult CKD patients and establish optimal treatment pathways.
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