Evidence map›Paper›PMID 35736952›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2022

Repeated warm water baths decrease sympathetic activity in humans.

Jian Cui, Zhaohui Gao, Urs A Leuenberger, Cheryl Blaha, Jonathan Carter Luck, Michael D Herr, Lawrence I Sinoway

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06932250 (Vascular and Neural Mechanisms of Chronic Leg Heating in Pregnant Women With Obesity), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06932250 narecruitingnot on this mapstarted 2025, after this paper: background citation

Vascular and Neural Mechanisms of Chronic Leg Heating in Pregnant Women With Obesity

TypeinterventionalSponsorUniversity of Texas Southwestern Medical CenterRan2025 to 2030Enrolled118ConditionsHigh-risk PregnancyArmsLeg heating
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Sympathetic nervous activation and hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jian CuiPenn State Heart and Vascular Institute, Pennsylvania State University College of Medicine, Hershey, Pennsylvania.ORCID 0000-0002-4015-9484
Zhaohui GaoPenn State Heart and Vascular Institute, Pennsylvania State University College of Medicine, Hershey, Pennsylvania.
Urs A LeuenbergerPenn State Heart and Vascular Institute, Pennsylvania State University College of Medicine, Hershey, Pennsylvania.
Cheryl BlahaPenn State Heart and Vascular Institute, Pennsylvania State University College of Medicine, Hershey, Pennsylvania.
Jonathan Carter LuckPenn State Heart and Vascular Institute, Pennsylvania State University College of Medicine, Hershey, Pennsylvania.ORCID 0000-0002-6964-3448
Michael D HerrPenn State Heart and Vascular Institute, Pennsylvania State University College of Medicine, Hershey, Pennsylvania.
Lawrence I SinowayPenn State Heart and Vascular Institute, Pennsylvania State University College of Medicine, Hershey, Pennsylvania.
Penn State Milton S. Hershey Medical Center · US

Funding

Penn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025
$33.7M
Exercise pressor reflex in peripheral artery disease: beneficial effects of heating and mechanismsR01HL141198 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI CUI, JIAN, LI, JIANHUA · 2019 to 2023
$3.7M
NCATS NIH HHS UL1 TR002014NHLBI NIH HHS R01 HL141198
6 · The paper itself

Abstract

Acute whole body heat stress evokes sympathetic activation. However, the chronic effects of repeated moderate heat exposure (RMHE) on muscle sympathetic nerve activity (MSNA) in healthy individuals remain unclear. We performed RMHE with 4 wk (5 days/wk) of warm baths (∼40°C, for 30 min) in nine healthy older (59 ± 2 yr) volunteers. Hemodynamic variables and MSNA were examined before, 1 day after, and 1 wk following 4 wk of RMHE in a laboratory at ∼23°C. Cold pressor test (CPT) and handgrip (HG) exercise were performed during the tests. Under normothermic condition, the resting MSNA burst rate (prior, post, post 1-wk: 31.6 ± 2.0, 25.2 ± 2.0, and 27.7 ± 1.7 bursts/min;

Indexed as

BathsHand StrengthBaroreflexBlood PressureHeart RateHumansMiddle AgedMuscle, SkeletalSympathetic Nervous SystemWaterWaterautonomicheart rate variabilityheat therapystresssympathetic

Identifiers

PMID35736952
PMCPMC9291418
OpenAlexW4283315412

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.