ArticleTomography (Ann Arbor, Mich.)2022
Magnetic Susceptibility Source Separation Solely from Gradient Echo Data: Histological Validation.
Article in Tomography (Ann Arbor, Mich.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Effects of iron repletion on brain iron content, myelination, neural network activation, and cognition.JCI insight · 2025Trial
- Comparison of iron and myelin changes in U‑fiber regions of relapsing-remitting multiple sclerosis and neuromyelitis optica spectrum disorders.Journal of neurology · 2026Article
- Tract-based χ-separation imaging differentiates multiple sclerosis from neuromyelitis optica spectrum disorder by mapping iron and myelin signatures.BMC medical imaging · 2026Article
- Tissue Reaction to Monofilament Grafts of Different Weights Used for Abdominal Wall Reinforcement.Biomedicines · 2026Article
- MRI Quantification of Liver Fibrosis Using Diamagnetic Susceptibility: An Ex Vivo Validation Study.Tomography (Ann Arbor, Mich.) · 2026Article
- Repeatability of Susceptibility Source Separation Methods in Human Brain: A Single-Site Study at 3 T.NMR in biomedicine · 2026Article
- Reduced myelin contributes to cognitive impairment in patients with monogenic small vessel disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Hemosiderin quantification in hemophilic arthropathy using quantitative magnetic resonance imaging.Scientific reports · 2025Article
- Quantitative Susceptibility Mapping with Source Separation in Normal Brain Development of Newborns.AJNR. American journal of neuroradiology · 2025Article
- A pilot study assessing the clinical utility of deep learning-reconstructed 3D-echo-planar-imaging-based quantitative susceptibility mapping in multiple sclerosis.Frontiers in neuroscience · 2025Article
- Distinguishing microgliosis and tau deposition in the mouse brain using paramagnetic and diamagnetic susceptibility source separation.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Paramagnetic rim lesions in early multiple sclerosis: a 7 Tesla imaging study.Brain communications · 2025Article
- Imaging chronic active lesions in multiple sclerosis: a consensus statement.Brain : a journal of neurology · 2024Review
- New Imaging Markers in Multiple Sclerosis and Related Disorders: Smoldering Inflammation and the Central Vein Sign.Neuroimaging clinics of North America · 2024Review
- So You Want to Image Myelin Using MRI: Magnetic Susceptibility Source Separation for Myelin Imaging.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2024Review
- Recommended implementation of quantitative susceptibility mapping for clinical research in the brain: A consensus of the ISMRM electro-magnetic tissue properties study group.Magnetic resonance in medicine · 2024Article
- Distinguishing microgliosis and tau deposition in the mouse brain using paramagnetic and diamagnetic susceptibility source separation.bioRxiv : the preprint server for biology · 2024Article
- Amyotrophic lateral sclerosis with upper motor neuron predominance: diagnostic accuracy of qualitative and quantitative susceptibility metrics in the precentral gyrus.European radiology · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Quantitative susceptibility mapping (QSM) facilitates mapping of the bulk magnetic susceptibility of tissue from the phase of complex gradient echo (GRE) MRI data. QSM phase processing combined with an R2* model of magnitude of multiecho gradient echo data (R2*QSM) allows separation of dia- and para-magnetic components (e.g., myelin and iron) that contribute constructively to R2* value but destructively to the QSM value of a voxel. This R2*QSM technique is validated against quantitative histology—optical density of myelin basic protein and Perls’ iron histological stains of rim and core of 10 ex vivo multiple sclerosis lesions, as well as neighboring normal appearing white matter. We found that R2*QSM source maps are in good qualitative agreement with histology, e.g., showing increased iron concentration at the edge of the rim+ lesions and myelin loss in the lesions’ core. Furthermore, our results indicate statistically significant correlation between paramagnetic and diamagnetic tissue components estimated with R2*QSM and optical densities of Perls’ and MPB stains. These findings provide direct support for the use of R2*QSM magnetic source separation based solely on GRE complex data to characterize MS lesion composition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.