Evidence map›Paper›PMID 35736459›Full record

ArticleMetabolites2022

mGWAS-Explorer: Linking SNPs, Genes, Metabolites, and Diseases for Functional Insights.

Le Chang, Guangyan Zhou, Huiting Ou, Jianguo Xia

Abstract read
In one paragraph

Article in Metabolites, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Le ChangDepartment of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada.ORCID 0000-0002-0966-7923
Guangyan ZhouInstitute of Parasitology, McGill University, Montreal, QC H9X 3V9, Canada.
Huiting OuDepartment of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada.ORCID 0000-0002-6039-4895
Jianguo XiaDepartment of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada.ORCID 0000-0003-2040-2624

Funding

Canada Research Chairs NAGenome Canada NANatural Sciences and Engineering Research Council NA
6 · The paper itself

Abstract

Tens of thousands of single-nucleotide polymorphisms (SNPs) have been identified to be significantly associated with metabolite abundance in over 65 genome-wide association studies with metabolomics (mGWAS) to date. Obtaining mechanistic or functional insights from these associations for translational applications has become a key research area in the mGWAS community. Here, we introduce mGWAS-Explorer, a user-friendly web-based platform to help connect SNPs, metabolites, genes, and their known disease associations via powerful network visual analytics. The application of the mGWAS-Explorer was demonstrated using a COVID-19 and a type 2 diabetes case studies.

Indexed as

cross-phenotype association analysismetabolomicsmGWASmQTLnetworkpleiotropySNP

Identifiers

PMID35736459
PMCPMC9230867

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.