Evidence map›Paper›PMID 35736182›Full record

ArticleMarine drugs2022

Photoinduced Synthesis of Methylated Marine Cyclopeptide Galaxamide Analogs with Isoindolinone as Anticancer Agents.

Shimei Xiao, Zhiqiang Wang, Huanli Zhang, Lei Zhao, Qingran Chang, Xiong Zhang, Rui Yan, Xiaodan Wu, Yingxue Jin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Shimei XiaoKey Laboratory of Photochemical Biomaterials and Energy Storage Materials, College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025, China.
Zhiqiang WangKey Laboratory of Photochemical Biomaterials and Energy Storage Materials, College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025, China.ORCID 0000-0002-5573-455X
Huanli ZhangKey Laboratory of Photochemical Biomaterials and Energy Storage Materials, College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025, China.
Lei ZhaoKey Laboratory of Photochemical Biomaterials and Energy Storage Materials, College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025, China.
Qingran ChangKey Laboratory of Photochemical Biomaterials and Energy Storage Materials, College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025, China.
Xiong ZhangKey Laboratory of Photochemical Biomaterials and Energy Storage Materials, College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025, China.
Rui YanKey Laboratory of Photochemical Biomaterials and Energy Storage Materials, College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025, China.
Xiaodan WuKey Laboratory of Photochemical Biomaterials and Energy Storage Materials, College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025, China.
Yingxue JinKey Laboratory of Photochemical Biomaterials and Energy Storage Materials, College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025, China.
Harbin Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The methylation of amino acid residues has played an important role in the biological function of bioactive peptides. In this paper, various methyl-modified and stereostructural-modified marine cyclopeptide galaxamide analogs with isoindolinone were synthesized by a photoinduced single electron transfer cyclization reaction. It was found that the single-methyl substitution was beneficial for the bioactivity of cyclic analogs with isoindolinone fragments, and the influence of methylation on bioactivity is uncertain and is sometimes case-specific. The compound with a single methyl group at Gly

Indexed as

Antineoplastic AgentsPeptides, CyclicCell Line, TumorCell ProliferationMolecular Docking SimulationPeptidesPhthalimidesAntineoplastic AgentsgalaxamidePeptidesPeptides, CyclicPhthalimidesphthalimidineantitumorcyclic peptidegalaxamidephotoinduced cyclizationstereochemistry

Identifiers

PMID35736182
PMCPMC9227305
OpenAlexW4281688788

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.