Evidence map›Paper›PMID 35736031›Full record

ReviewJournal of fungi (Basel, Switzerland)2022

Respiratory Epithelial Cells: More Than Just a Physical Barrier to Fungal Infections.

Bianca C S C Barros, Bruna R Almeida, Debora T L Barros, Marcos S Toledo, Erika Suzuki

Open access · goldAbstract readReview
In one paragraph

Review in Journal of fungi (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. RBMX2 linkseLife · 2025
    Article
  4. Article
  5. Article
  6. Journal of fungi (Basel, Switzerland) · 2023
    Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Bianca C S C BarrosLaboratory of Applied Toxinology, Center of Toxins, Immune-Response and Cell Signaling (CeTICS), Butantan Institute, São Paulo 05503-900, SP, Brazil.ORCID 0000-0002-6915-0707
Bruna R AlmeidaDepartment of Microbiology, Immunology, and Parasitology, Escola Paulista de Medicina, Universidade Federal de São Paulo, Ed. Antonio C. M. Paiva, São Paulo 04023-062, SP, Brazil.ORCID 0000-0002-3726-1752
Debora T L BarrosDepartment of Microbiology, Immunology, and Parasitology, Escola Paulista de Medicina, Universidade Federal de São Paulo, Ed. Antonio C. M. Paiva, São Paulo 04023-062, SP, Brazil.
Marcos S ToledoDepartment of Biochemistry, Escola Paulista de Medicina, Universidade Federal de São Paulo, Ed. Leal Prado, São Paulo 04023-062, SP, Brazil.
Erika SuzukiDepartment of Microbiology, Immunology, and Parasitology, Escola Paulista de Medicina, Universidade Federal de São Paulo, Ed. Antonio C. M. Paiva, São Paulo 04023-062, SP, Brazil.ORCID 0000-0002-4010-8716
Universidade Federal de São Paulo · BRInstituto Butantan · BR

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior 88887.670584/2022-00National Council for Scientific and Technological Development 170209/2018-0São Paulo Research Foundation 2019/26693-9
6 · The paper itself

Abstract

The respiratory epithelium is highly complex, and its composition varies along the conducting airways and alveoli. In addition to their primary function in maintaining the respiratory barrier and lung homeostasis for gas exchange, epithelial cells interact with inhaled pathogens, which can manipulate cell signaling pathways, promoting adhesion to these cells or hosting tissue invasion. Moreover, pathogens (or their products) can induce the secretion of chemokines and cytokines by epithelial cells, and in this way, these host cells communicate with the immune system, modulating host defenses and inflammatory outcomes. This review will focus on the response of respiratory epithelial cells to two human fungal pathogens that cause systemic mycoses:

Indexed as

adhesionairwayAspergilluscytokineepithelial cellinvasionlungParacoccidioidesrespiratory

Identifiers

PMID35736031
PMCPMC9225092
OpenAlexW4283396246

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.