Evidence map›Paper›PMID 35735992›Full record

ArticleJournal of bacteriology2022

Interplay of CodY and CcpA in Regulating Central Metabolism and Biofilm Formation in Staphylococcus aureus.

Logan L Bulock, Jongsam Ahn, Dhananjay Shinde, Sanjit Pandey, Cleofes Sarmiento, Vinai C Thomas, Chittibabu Guda, Kenneth W Bayles, Marat R Sadykov

Open access · greenAbstract read
In one paragraph

Article in Journal of bacteriology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Understanding bacterial biofilms: From definition to treatment strategies.Frontiers in cellular and infection microbiology · 2023
    Pooled it
  2. mBio · 2026
    Article
  3. Article
  4. D-alanine aminotransferase (Dat) promotesbioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Journal of bacteriology · 2025
    Article
  12. Article
  13. Characterizing theJournal of bacteriology · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Logan L BulockDepartment of Pathology and Microbiology, University of Nebraska Medical Centergrid.266813.8, Omaha, Nebraska, USA.
Jongsam AhnDepartment of Pathology and Microbiology, University of Nebraska Medical Centergrid.266813.8, Omaha, Nebraska, USA.
Dhananjay ShindeDepartment of Pathology and Microbiology, University of Nebraska Medical Centergrid.266813.8, Omaha, Nebraska, USA.
Sanjit PandeyDepartment of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Centergrid.266813.8, Omaha, Nebraska, USA.
Cleofes SarmientoDepartment of Pathology and Microbiology, University of Nebraska Medical Centergrid.266813.8, Omaha, Nebraska, USA.
Vinai C ThomasDepartment of Pathology and Microbiology, University of Nebraska Medical Centergrid.266813.8, Omaha, Nebraska, USA.ORCID 0000-0002-7886-0727
Chittibabu GudaDepartment of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Centergrid.266813.8, Omaha, Nebraska, USA.ORCID 0000-0002-5393-9316
Kenneth W BaylesDepartment of Pathology and Microbiology, University of Nebraska Medical Centergrid.266813.8, Omaha, Nebraska, USA.
Marat R SadykovDepartment of Pathology and Microbiology, University of Nebraska Medical Centergrid.266813.8, Omaha, Nebraska, USA.ORCID 0000-0001-7090-1929
University of Nebraska Medical Center · US

Funding

UNMC Structural Biology CoreP20GM103427 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI PAUL L SORGEN · 2012 to 2026
$59.2M
UNMC/EPPLEY CANCER CENTER SUPPORT GRANTP30CA036727 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Joann B. Sweasy · 1985 to 2026
$55.0M
The S. aureus biofilm lifecycleP01AI083211 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KIELIAN, TAMMY L · 2009 to 2023
$32.1M
The role of arginine catabolic pathways in modulating staphylococcal fitnessR01AI125588 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI THOMAS, VINAI · 2018 to 2022
$1.9M
The molecular control of bacterial programmed cell deathR01AI125589 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BAYLES, KENNETH W. · 2016 to 2020
$1.9M
NCI NIH HHS P30 CA036727NIAID NIH HHS P01 AI083211NIAID NIH HHS R01 AI125588NIAID NIH HHS R01 AI125589NIGMS NIH HHS P20 GM103427
6 · The paper itself

Abstract

Staphylococcus aureus is a medically important pathogen with high metabolic versatility allowing it to infect various niches within a host. S. aureus utilizes two major transcriptional regulators, namely, CodY and CcpA, to remodel metabolic and virulence gene expression in response to changing environmental conditions. Previous studies revealed that inactivation of either

Indexed as

Staphylococcal InfectionsStaphylococcus aureusBacterial ProteinsBiofilmsGene Expression Regulation, BacterialHumansBacterial Proteinsbiofilm developmentmetabolismStaphylococcus aureustranscriptional regulationvirulence

Identifiers

PMID35735992
PMCPMC9295537
OpenAlexW4283315054

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.