Evidence map›Paper›PMID 35735934›Full record

ArticleJournal of functional biomaterials2022

Effect of a Self-Assembly Peptide on Surface Roughness and Hardness of Bleached Enamel.

Gabriela de A P Magalhães, May Anny A Fraga, Isaac J de Souza Araújo, Rafael R Pacheco, Américo B Correr, Regina M Puppin-Rontani

Open access · goldAbstract read
In one paragraph

Article in Journal of functional biomaterials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Article
  3. AnInternational journal of clinical pediatric dentistry · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Peptides in Dentistry: A Scoping Review.Bioengineering (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Gabriela de A P MagalhãesDepartment of Restorative Dentistry, Dental Materials Division, Piracicaba Dental School, UNICAMP, State University of Campinas, Piracicaba 13414903, Brazil.ORCID 0000-0002-7001-8850
May Anny A FragaDepartment of Restorative Dentistry, Dental Materials Division, Piracicaba Dental School, UNICAMP, State University of Campinas, Piracicaba 13414903, Brazil.
Isaac J de Souza AraújoDepartment of Restorative Dentistry, Dental Materials Division, Piracicaba Dental School, UNICAMP, State University of Campinas, Piracicaba 13414903, Brazil.ORCID 0000-0002-1795-8640
Rafael R PachecoDepartment of Restorative Dentistry, University of Detroit Mercy School of Dentistry, Detroit, 48208 MI, USA.
Américo B CorrerDepartment of Restorative Dentistry, Dental Materials Division, Piracicaba Dental School, UNICAMP, State University of Campinas, Piracicaba 13414903, Brazil.
Regina M Puppin-RontaniDepartment of Health Sciences and Pediatric Dentistry, Pediatric Division, Piracicaba Dental School, UNICAMP, State University of Campinas, Piracicaba 13414903, Brazil.ORCID 0000-0002-1218-5159
Universidade Estadual de Campinas (UNICAMP) · BRUniversity of Detroit Mercy · US

Funding

Coordination for the Improvement of Higher Education Personnel (CAPES) Code 001
6 · The paper itself

Abstract

After bleaching, enamel surfaces are damaged, contributing to erosion and tooth sensitivity. Although fluoride is used after bleaching to try and revert alterations, it is not capable of repairing tooth structure. This study compared the effect of a self-assembly peptide (P11-4), with and without fluoride, and sodium fluoride (NaF 2%) on the Knoop microhardness (KHN) and surface roughness (Ra (μm)) of bleached enamel with an in-office bleaching regimen. Enamel blocks of bovine teeth (5 × 5 × 2 mm) with standardized surface hardness were bleached with 35% carbamide peroxide, following the manufacturer’s instructions. The teeth were randomly divided into the following groups (n = 7) according to post-bleaching treatment: no treatment (negative control) (C-); 2% NaF (NaF); Curodont™ Repair (Repair); and Curodont™ Protect (Protect). Specimens were stored in artificial saliva at 37 °C. To evaluate the effect of the post-bleaching treatments, KHN and Ra were measured before bleaching (baseline) and 24 h and 7 days after bleaching. Data were submitted to repeated measures ANOVA and Bonferroni tests (α = 0.05). There were significant interactions between the study factors (p = 0.001). After 7 days, Repair (572.50 ± 79.04) and Protect (583.00 ± 74.76) specimens showed increased surface KHN, with values higher than the NaF (465.50 ± 41.50) and C- (475.22 ± 58.95) baseline values. There was no significant difference in KHN at 24 h among groups (p = 0.587). At 24 h after bleaching, Repair was significantly different from all groups (p < 0.05). Repair showed the lowest Ra (μm) values (0.133 ± 0.035). After seven days, there was no significant difference in Ra values among groups when compared to the baseline. The use of P11-4-based materials after bleaching resulted in the fastest recovery to baseline enamel properties.

Indexed as

hardnessroughnessself-assembly peptidesodium fluoridetooth bleachingtooth remineralization

Identifiers

PMID35735934
PMCPMC9224554
OpenAlexW4282600972

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.