Evidence map›Paper›PMID 35735932›Full record

ReviewJournal of functional biomaterials2022

Graphene Oxide (GO) Materials-Applications and Toxicity on Living Organisms and Environment.

Aminah N Ghulam, Otávio A L Dos Santos, Layla Hazeem, Bianca Pizzorno Backx, Mohamed Bououdina, Stefano Bellucci

Abstract readReview
In one paragraph

Review in Journal of functional biomaterials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

  1. Green synthesis nanocomposite GO/ZnFeScientific reports · 2026
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  17. Holistic Investigation of Graphene Quantum Dot Endocytosis.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Aminah N GhulamDepartment of Biology, College of Science, University of Bahrain, Zallaq P.O. Box 32038, Bahrain.
Otávio A L Dos SantosInstituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.ORCID 0000-0002-5411-3575
Layla HazeemDepartment of Biology, College of Science, University of Bahrain, Zallaq P.O. Box 32038, Bahrain.
Bianca Pizzorno BackxNumpex-Bio, Universidade Federal do Rio de Janeiro, Campus Duque de Caxias, Duque de Caxias 25245-390, Brazil.ORCID 0000-0001-6508-0636
Mohamed BououdinaDepartment of Mathematics and Sciences, Faculty of Humanities and Sciences, Prince Sultan University, Riyadh 11586, Saudi Arabia.
Stefano BellucciINFN-Laboratori Nazionali di Frascati, Via E. Fermi 54, 00044 Frascati, Italy.ORCID 0000-0003-0326-6368

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Graphene-based materials have attracted much attention due to their fascinating properties such as hydrophilicity, high dispersion in aqueous media, robust size, high biocompatibility, and surface functionalization ability due to the presence of functional groups and interactions with biomolecules such as proteins and nucleic acid. Modified methods were developed for safe, direct, inexpensive, and eco-friendly synthesis. However, toxicity to the environment and animal health has been reported, raising concerns about their utilization. This review focuses primarily on the synthesis methods of graphene-based materials already developed and the unique properties that make them so interesting for different applications. Different applications are presented and discussed with particular emphasis on biological fields. Furthermore, antimicrobial potential and the factors that affect this activity are reviewed. Finally, questions related to toxicity to the environment and living organisms are revised by highlighting factors that may interfere with it.

Indexed as

cytotoxicityenvironmentgraphene derivativeshealth

Identifiers

PMID35735932
PMCPMC9224660

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.