ArticleJournal of functional biomaterials2022
Self-Crosslinkable Oxidized Alginate-Carboxymethyl Chitosan Hydrogels as an Injectable Cell Carrier for In Vitro Dental Enamel Regeneration.
Article in Journal of functional biomaterials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Mesenchymal Stem Cell-Laden Nanofibril-Reinforced Injectable and Self-Healing Alginate Dialdehyde/Gelatin Hydrogels with Enhanced Mechanical and Chondrogenic Performance In Vitro.Macromolecular bioscience · 2026Article
- Advancement in Sodium Alginate-Based Drug Delivery Systems: Applications and Future Prospects.AAPS PharmSciTech · 2026Review
- Article
- A self-healing hydrogel based on modified chitosan and sodium alginate oxide reinforced with hydrophilic nanomaterials for wound dressing applications.Journal of materials science. Materials in medicine · 2026Article
- Development and Characterization of an Injectable Alginate/Chitosan Composite Hydrogel Reinforced with Cyclic-RGD Functionalized Graphene Oxide for Potential Tissue Regeneration Applications.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Bioprinting vascularized skin analogs: a stepwise approach.Burns & trauma · 2025Review
- Chitosan-based Nano/Biomaterials in Bone Tissue Engineering and Regenerative Medicine: Recent Progress and Advances.Current organic synthesis · 2025Review
- Applications and interventions of polymers and nanomaterials in alveolar bone regeneration and tooth dentistry.RSC advances · 2024Review
- Preservation of freshly-cut lemon slices using alginate-based coating functionalized with antioxidant enzymatically hydrolyzed rice straw-hemicellulose.Scientific reports · 2024Article
- Review
- How the combination of alginate and chitosan can fabricate a hydrogel with favorable properties for wound healing.Heliyon · 2024Review
- Biomaterials / bioinks and extrusion bioprinting.Bioactive materials · 2023Review
- Role of Chitosan Hydrogels in Clinical Dentistry.Gels (Basel, Switzerland) · 2023Review
- State of Innovation in Alginate-Based Materials.Marine drugs · 2023Review
- Research Advances on Hydrogel-Based Materials for Tissue Regeneration and Remineralization in Tooth.Gels (Basel, Switzerland) · 2023Review
- Alginate-Based Biomaterials in Tissue Engineering and Regenerative Medicine.Marine drugs · 2023Review
- Chitosan-Based Biomaterials for Tissue Regeneration.Pharmaceutics · 2023Review
- Applications of Hydrogels in Drug Delivery for Oral and Maxillofacial Diseases.Gels (Basel, Switzerland) · 2023Review
- A Comprehensive Review of Cross-Linked Gels as Vehicles for Drug Delivery to Treat Central Nervous System Disorders.Gels (Basel, Switzerland) · 2022Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Injectable hydrogels, as carriers, offer great potential to incorporate cells or growth factors for dental tissue regeneration. Notably, the development of injectable hydrogels with appropriate structures and properties has been a challenging task, leaving much to be desired in terms of cytocompatibility, antibacterial and self-healing properties, as well as the ability to support dental stem cell functions. This paper presents our study on the development of a novel self-cross-linkable hydrogel composed of oxidized alginate and carboxymethyl chitosan and its characterization as a cell carrier for dental enamel regeneration in vitro. Oxidized alginate was synthesized with 60% theoretical oxidation degree using periodate oxidation and characterized by Fourier Transform Infrared spectroscopy, proton nuclear magnetic resonance spectroscopy, and Ultraviolet-visible absorption spectroscopy. Then, hydrogels were prepared at three varying weight ratios of oxidized alginate to carboxymethyl chitosan (4:1, 3:1, and 2:1) through Schiff base reactions, which was confirmed by Fourier Transform Infrared spectroscopy. The hydrogels were characterized in terms of gelation time, swelling ratio, structure, injectability, self-healing, antibacterial properties, and in vitro characterization for enamel regeneration. The results demonstrated that, among the three hydrogels examined, the one with the highest ratio of oxidized alginate (i.e., 4:1) had the fastest gelation time and the lowest swelling ability, and that all hydrogels were formed with highly porous structures and were able to be injected through a 20-gauge needle without clogging. The injected hydrogels could be rapidly reformed with the self-healing property. The hydrogels also showed antibacterial properties against two cariogenic bacteria:
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.