ArticleeLife2022
Cognitive experience alters cortical involvement in goal-directed navigation.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Inferring brain-wide interactions using data-constrained recurrent neural network models.Neuron · 2026Article
- Addressing degeneracy in rodent studies of cognition.Current opinion in neurobiology · 2026Review
- Cortex-wide characterization of decision-making neural dynamics during spatial navigation.Nature communications · 2026Article
- Data-derived agents reveal dynamical reservoirs in mouse cortex for adaptive behavior.bioRxiv : the preprint server for biology · 2026Article
- Contextual inference through flexible integration of environmental features and behavioural outcomes.PLoS computational biology · 2026Article
- Article
- How distributed is the brain-wide network that is recruited for cognition?Nature reviews. Neuroscience · 2026Review
- Routing of task-relevant information in mouse PPC during continuous visuomotor control.bioRxiv : the preprint server for biology · 2025Article
- Parietal cortex is causally required for state-dependent decisions.Cell reports · 2025Article
- Specialized structure of neural population codes in parietal cortex outputs.Nature neuroscience · 2025Article
- Working memory expands shared task representations in cortex.bioRxiv : the preprint server for biology · 2025Article
- Parietal cortex is causally required for state-dependent decisions.bioRxiv : the preprint server for biology · 2025Article
- Coordinated multi-level adaptations across neocortical areas during task learning.Nature communications · 2025Article
- Cognitive processes are disentangled at cortex-wide scales.bioRxiv : the preprint server for biology · 2025Article
- Article
- POCO: Scalable Neural Forecasting through Population Conditioning.Advances in neural information processing systems · 2025Article
- The role of motor cortex in motor sequence execution depends on demands for flexibility.Nature neuroscience · 2024Article
- Article
- The Neural and Computational Architecture of Feedback Dynamics in Mouse Cortex during Stimulus Report.eNeuro · 2024Article
- Single neuron responses to perceptual difficulty in the mouse auditory cortex.Science advances · 2024Article
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9 authors.
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Abstract
Neural activity in the mammalian cortex has been studied extensively during decision tasks, and recent work aims to identify under what conditions cortex is actually necessary for these tasks. We discovered that mice with distinct cognitive experiences, beyond sensory and motor learning, use different cortical areas and neural activity patterns to solve the same navigation decision task, revealing past learning as a critical determinant of whether cortex is necessary for goal-directed navigation. We used optogenetics and calcium imaging to study the necessity and neural activity of multiple cortical areas in mice with different training histories. Posterior parietal cortex and retrosplenial cortex were mostly dispensable for accurate performance of a simple navigation task. In contrast, these areas were essential for the same simple task when mice were previously trained on complex tasks with delay periods or association switches. Multiarea calcium imaging showed that, in mice with complex-task experience, single-neuron activity had higher selectivity and neuron-neuron correlations were weaker, leading to codes with higher task information. Therefore, past experience is a key factor in determining whether cortical areas have a causal role in goal-directed navigation.
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