Evidence map›Paper›PMID 35735741›Full record

ArticleAndrology2022

The European Academy of Andrology (EAA) ultrasound study on healthy, fertile men: Prostate-vesicular transrectal ultrasound reference ranges and associations with clinical, seminal and biochemical characteristics.

Francesco Lotti, Francesca Frizza, Giancarlo Balercia, Arcangelo Barbonetti, Hermann M Behre, Aldo E Calogero, Jann-Frederik Cremers, Felice Francavilla, Andrea M Isidori, Sabine Kliesch and 22 more

Abstract readMulticenter Study
In one paragraph

Article in Andrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  13. Beyond the Basics: Best Practices in Scrotal Ultrasound for the Infertile Male.International braz j urol : official journal of the Brazilian Society of Urology
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Francesco LottiAndrology, Female Endocrinology and Gender Incongruence Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy.ORCID 0000-0001-8343-1807
Francesca FrizzaAndrology, Female Endocrinology and Gender Incongruence Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy.
Giancarlo BalerciaEndocrinology Unit, Ospedali Riuniti Ancona, Polytechnic University of Marche, Ancona, Italy.
Arcangelo BarbonettiAndrology Unit, Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
Hermann M BehreCenter for Reproductive Medicine and Andrology, Martin Luther University Halle-Wittenberg, Halle, Germany.
Aldo E CalogeroDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy.ORCID 0000-0001-6950-335X
Jann-Frederik CremersDepartment of Clinical and Surgical Andrology, Centre of Reproductive Medicine and Andrology, Münster University Hospital, Münster, Germany.
Felice FrancavillaAndrology Unit, Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
Andrea M IsidoriDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.ORCID 0000-0002-9037-5417
Sabine KlieschDepartment of Clinical and Surgical Andrology, Centre of Reproductive Medicine and Andrology, Münster University Hospital, Münster, Germany.ORCID 0000-0002-7561-4870
Sandro La VigneraDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy.ORCID 0000-0002-7113-2372
Andrea LenziDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Marios MarcouCenter for Reproductive Medicine and Andrology, Martin Luther University Halle-Wittenberg, Halle, Germany.
Adrian PilatzDepartment of Urology, Pediatric Urology and Andrology, Justus Liebig University, Giessen, Germany.ORCID 0000-0001-8072-1841
Olev PoolametsAndrology Unit, Tartu University Hospital, Tartu, Estonia.
Margus PunabAndrology Unit, Tartu University Hospital, Tartu, Estonia.
Maria Fernanda Peraza GodoyAndrology Department, Fundació Puigvert, Universitat Autònoma de Barcelona, Instituto de Investigaciones Biomédicas Sant Pau (IIB-Sant Pau), Barcelona, Spain.
Claudia QuintianAndrology Department, Fundació Puigvert, Universitat Autònoma de Barcelona, Instituto de Investigaciones Biomédicas Sant Pau (IIB-Sant Pau), Barcelona, Spain.
Osvaldo RajmilAndrology Department, Fundació Puigvert, Universitat Autònoma de Barcelona, Instituto de Investigaciones Biomédicas Sant Pau (IIB-Sant Pau), Barcelona, Spain.ORCID 0000-0003-1987-9206
Gianmaria SalvioEndocrinology Unit, Ospedali Riuniti Ancona, Polytechnic University of Marche, Ancona, Italy.
Osama ShaeerDepartment of Andrology, Kasr El Aini Faculty of Medicine, Cairo University, Cairo, Egypt.
Wolfgang WeidnerDepartment of Urology, Pediatric Urology and Andrology, Justus Liebig University, Giessen, Germany.
Elisa MaseroliAndrology, Female Endocrinology and Gender Incongruence Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy.
Sarah CiprianiAndrology, Female Endocrinology and Gender Incongruence Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy.
Elisabetta BaldiAndrology, Female Endocrinology and Gender Incongruence Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy.
Selene Degl'InnocentiAndrology, Female Endocrinology and Gender Incongruence Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy.
Giovanna DanzaEndocrinology Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy.
Anna Lucia CaldiniDepartment of Laboratory, Careggi Hospital, Florence, Italy.
Alessandro TerreniDepartment of Laboratory, Careggi Hospital, Florence, Italy.
Luca BoniClinical Trials Coordinating Center, Toscano Cancer Institute, University Hospital Careggi, Florence, Italy.
Csilla KrauszAndrology, Female Endocrinology and Gender Incongruence Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy.
Mario MaggiEndocrinology Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTransrectal ultrasound (TRUS) parameters are not standardized, especially in men of reproductive age. Hence, the European Academy of Andrology (EAA) promoted a multicenter study to assess the TRUS characteristics of healthy-fertile men (HFM) to establish normative parameters.

objectivesTo report and discuss the prostate and seminal vesicles (SV) reference ranges and characteristics in HFM and their associations with clinical, seminal, biochemical parameters.

methods188 men (35.6 ± 6.0 years) from a cohort of 248 HFM were studied, evaluating, on the same day, clinical, biochemical, seminal, TRUS parameters following Standard Operating Procedures.

resultsTRUS reference ranges and characteristics of the prostate and SV of HFM are reported herein. The mean PV was ∼25 ml. PV lower and upper limits were 15 and 35 ml, defining prostate hypotrophy and enlargement, respectively. PV was positively associated with age, waistline, current smoking (but not with T levels), seminal volume (and negatively with seminal pH), prostate inhomogeneity, macrocalcifications, calcification size and prostate arterial parameters, SV volume before and after ejaculation, deferential and epididymal size. Prostate calcifications and inhomogeneity were frequent, while midline prostatic cysts were rare and small. Ejaculatory duct abnormalities were absent. Periprostatic venous plexus size was positively associated with prostate calcifications, SV volume and arterial peak systolic velocity. Lower and upper limits of SV anterior-posterior diameter after ejaculation were 6 and 16 mm, defining SV hypotrophy or dilation, respectively. SV total volume before ejaculation and delta SV total volume (DSTV) positively correlated with ejaculate volume, and DSTV correlated positively with sperm progressive motility. SV total volume after ejaculation was associated negatively with SV ejection fraction and positively with distal ampullas size. SV US abnormalities were rare. No association between TRUS and time to pregnancy, number of children or history of miscarriage was observed.

conclusionsThe present findings will help in better understanding male infertility pathophysiology and the meaning of specific TRUS findings.

Indexed as

AndrologyProstateChildEjaculatory DuctsFemaleHumansMalePregnancyReference ValuesSemenSeminal VesiclesUltrasonographyclinical, seminal, hormonal and metabolic parametersHealthy, fertile menprostate and seminal vesicles reference ranges and normative parameterstransrectal ultrasound

Identifiers

PMID35735741
PMCPMC9544532

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.