Evidence map›Paper›PMID 35735726›Full record

ArticleGels (Basel, Switzerland)2022

RGD-Functionalized Hydrogel Supports the Chondrogenic Commitment of Adipose Mesenchymal Stromal Cells.

Cristina Manferdini, Diego Trucco, Yasmin Saleh, Elena Gabusi, Paolo Dolzani, Enrico Lenzi, Lorenzo Vannozzi, Leonardo Ricotti, Gina Lisignoli

Open access · goldAbstract read
In one paragraph

Article in Gels (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Cristina ManferdiniIRCCS Istituto Ortopedico Rizzoli, SC Laboratorio di Immunoreumatologia e Rigenerazione Tissutale, 40136 Bologna, Italy.ORCID 0000-0002-6648-6061
Diego TruccoIRCCS Istituto Ortopedico Rizzoli, SC Laboratorio di Immunoreumatologia e Rigenerazione Tissutale, 40136 Bologna, Italy.ORCID 0000-0002-1806-1309
Yasmin SalehIRCCS Istituto Ortopedico Rizzoli, SC Laboratorio di Immunoreumatologia e Rigenerazione Tissutale, 40136 Bologna, Italy.
Elena GabusiIRCCS Istituto Ortopedico Rizzoli, SC Laboratorio di Immunoreumatologia e Rigenerazione Tissutale, 40136 Bologna, Italy.
Paolo DolzaniIRCCS Istituto Ortopedico Rizzoli, SC Laboratorio di Immunoreumatologia e Rigenerazione Tissutale, 40136 Bologna, Italy.
Enrico LenziIRCCS Istituto Ortopedico Rizzoli, SC Laboratorio di Immunoreumatologia e Rigenerazione Tissutale, 40136 Bologna, Italy.
Lorenzo VannozziThe BioRobotics Institute, Scuola Superiore Sant'Anna, 56025 Pisa, Italy.ORCID 0000-0003-3525-5073
Leonardo RicottiThe BioRobotics Institute, Scuola Superiore Sant'Anna, 56025 Pisa, Italy.
Gina LisignoliIRCCS Istituto Ortopedico Rizzoli, SC Laboratorio di Immunoreumatologia e Rigenerazione Tissutale, 40136 Bologna, Italy.ORCID 0000-0003-2837-9967
Istituto Ortopedico Rizzoli · ITScuola Superiore Sant'Anna · IT

Funding

European Union's Horizon 2020 research and innovation program, grant agreement No 814413, project ADMAIORA (AdvanceD nanocomposite MAterIals fOr in situ treatment and ultRAsound-mediated management of osteoarthritis). 814413
6 · The paper itself

Abstract

Articular cartilage is known to have limited intrinsic self-healing capacity when a defect or a degeneration process occurs. Hydrogels represent promising biomaterials for cell encapsulation and injection in cartilage defects by creating an environment that mimics the cartilage extracellular matrix. The aim of this study is the analysis of two different concentrations (1:1 and 1:2) of VitroGel

Indexed as

adipose mesenchymal stromal cellscartilage regenerationchondrogenic differentiationhydrogel characterizationhydrogelsRGD motif

Identifiers

PMID35735726
PMCPMC9222613
OpenAlexW4282967678

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.