Evidence map›Paper›PMID 35735704›Full record

ReviewGels (Basel, Switzerland)2022

Poloxamer-Based Scaffolds for Tissue Engineering Applications: A Review.

Naiyu Cui, Chun-Yu Dai, Xuran Mao, Xun Lv, Yue Gu, Eui-Seok Lee, Heng-Bo Jiang, Yunhan Sun

Open access · goldAbstract readReview
In one paragraph

Review in Gels (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Recombinant Human Amelogenin Protein Enhances Healing of Osteochondral Injury in a Goat Model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. OnyxGels (Basel, Switzerland) · 2024
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Naiyu CuiThe CONVERSATIONALIST Club, School of Stomatology, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai'an 271016, China.
Chun-Yu DaiThe CONVERSATIONALIST Club, School of Stomatology, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai'an 271016, China.ORCID 0000-0002-8334-8955
Xuran MaoThe CONVERSATIONALIST Club, School of Stomatology, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai'an 271016, China.ORCID 0000-0002-9607-4498
Xun LvThe CONVERSATIONALIST Club, School of Stomatology, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai'an 271016, China.ORCID 0000-0001-7961-0271
Yue GuThe CONVERSATIONALIST Club, School of Stomatology, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai'an 271016, China.
Eui-Seok LeeDepartment of Oral and Maxillofacial Surgery, Graduate School of Clinical Dentistry, Korea University, Seoul 08308, Korea.
Heng-Bo JiangThe CONVERSATIONALIST Club, School of Stomatology, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai'an 271016, China.ORCID 0000-0002-2514-2633
Yunhan SunThe CONVERSATIONALIST Club, School of Stomatology, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai'an 271016, China.ORCID 0000-0001-8641-0825
Shandong First Medical University · CNKorea University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Poloxamer is a triblock copolymer with amphiphilicity and reversible thermal responsiveness and has wide application prospects in biomedical applications owing to its multifunctional properties. Poloxamer hydrogels play a crucial role in the field of tissue engineering and have been regarded as injectable scaffolds for loading cells or growth factors (GFs) in the last few years. Hydrogel micelles can maintain the integrity and stability of cells and GFs and form an appropriate vascular network at the application site, thus creating an appropriate microenvironment for cell growth, nerve growth, or bone integration. The injectability and low toxicity of poloxamer hydrogels make them a noninvasive method. In addition, they can also be good candidates for bio-inks, the raw material for three-dimensional (3D) printing. However, the potential of poloxamer hydrogels has not been fully explored owing to the complex biological challenges. In this review, the latest progress and cutting-edge research of poloxamer-based scaffolds in different fields of application such as the bone, vascular, cartilage, skin, nervous system, and organs in tissue engineering and 3D printing are reviewed, and the important roles of poloxamers in tissue engineering scaffolds are discussed in depth.

Indexed as

3D printingbiomaterialshydrogel scaffoldspoloxamertissue engineering

Identifiers

PMID35735704
PMCPMC9222596
OpenAlexW4281672633

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.