ArticleGels (Basel, Switzerland)2022
Electrospun Core (HPMC-Acetaminophen)-Shell (PVP-Sucralose) Nanohybrids for Rapid Drug Delivery.
Article in Gels (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Strategically Designed Coaxial Electrospun Nanofibers of Polylactic Acid/Glycerol Monolaurate Hydroxypropyl-Foods (Basel, Switzerland) · 2026Article
- Wound Dressing with Electrospun Core-Shell Nanofibers: From Material Selection to Synthesis.Polymers · 2024Review
- Article
- Multi-material electrospinning: from methods to biomedical applications.Materials today. Bio · 2023Review
- Electrospun self-emulsifying core-shell nanofibers for effective delivery of paclitaxel.Frontiers in bioengineering and biotechnology · 2023Article
- Growth Factor Binding Peptides in Poly (Ethylene Glycol) Diacrylate (PEGDA)-Based Hydrogels for an Improved Healing Response of Human Dermal Fibroblasts.Gels (Basel, Switzerland) · 2022Article
- Delivery of streptomycin to the rat colon by use of electrospun nanofibers.Scientific reports · 2022Article
- Progress of Electrospun Nanofibrous Carriers for Modifications to Drug Release Profiles.Journal of functional biomaterials · 2022Review
- Editorial on the Special Issue "Advances in Cellulose-Based Hydrogels".Gels (Basel, Switzerland) · 2022Article
- Optimization of process parameters for fabrication of electrospun nanofibers containing neomycin sulfate andDrug delivery · 2022Article
- Advances in the Preparation of Nanofiber Dressings by Electrospinning for Promoting Diabetic Wound Healing.Biomolecules · 2022Review
- Article
- Processes of Electrospun Polyvinylidene Fluoride-Based Nanofibers, Their Piezoelectric Properties, and Several Fantastic Applications.Polymers · 2022Review
- Review
- Advances in the Application of Electrospun Drug-Loaded Nanofibers in the Treatment of Oral Ulcers.Biomolecules · 2022Review
- Electrospun Zein/Polyoxyethylene Core-Sheath Ultrathin Fibers and Their Antibacterial Food Packaging Applications.Biomolecules · 2022Article
- Review
- Electrospun Core-Sheath Nanofibers with Variable Shell Thickness for Modifying Curcumin Release to Achieve a Better Antibacterial Performance.Biomolecules · 2022Article
- Electrospun Nanofibers for Periodontal Treatment: A Recent Progress.International journal of nanomedicine · 2022Review
- Electrospun nanofiber-based glucose sensors for glucose detection.Frontiers in chemistry · 2022Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gels of cellulose and its derivatives have a broad and deep application in pharmaceutics; however, limited attention has been paid to the influences of other additives on the gelation processes and their functional performances. In this study, a new type of electrospun core-shell nanohybrid was fabricated using modified, coaxial electrospinning which contained composites of hydroxypropyl methyl cellulose (HPMC) and acetaminophen (AAP) in the core sections and composites of PVP and sucralose in the shell sections. A series of characterizations demonstrated that the core-shell hybrids had linear morphology with clear core-shell nanostructures, and AAP and sucralose distributed in the core and shell section in an amorphous state separately due to favorable secondary interactions such as hydrogen bonding. Compared with the electrospun HPMC-AAP nanocomposites from single-fluid electrospinning of the core fluid, the core-shell nanohybrids were able to promote the water absorbance and HMPC gelation formation processes, which, in turn, ensured a faster release of AAP for potential orodispersible drug delivery applications. The mechanisms of the drug released from these nanofibers were demonstrated to be a combination of erosion and diffusion mechanisms. The presented protocols pave a way to adjust the properties of electrospun, cellulose-based, fibrous gels for better functional applications.
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