ArticleGels (Basel, Switzerland)2022
Development of Bigels Based on Date Palm-Derived Cellulose Nanocrystal-Reinforced Guar Gum Hydrogel and Sesame Oil/Candelilla Wax Oleogel as Delivery Vehicles for Moxifloxacin.
Article in Gels (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Fabrication and characterization of novel bigel systems based on natural gums: rheological, textural, and thermal properties.Journal of biological engineering · 2026Article
- Development and fabrication of apricot kernel oil-based oleogels for enhanced ocular delivery of lifitegrast in dry eye management.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Engineering a Nanostructured Hybrid Gel System with Sodium Humate for Enhanced Wound Healing.Journal of functional biomaterials · 2026Article
- Amphotericin B-Loaded Bigel: Characterization and in vivo Antileishmanial Evaluation in BALB/c Mice Infected with Leishmania amazonensis.AAPS PharmSciTech · 2026Article
- Development and Characterization of Emulsion-Templated Oleogels from Whey Protein and Spent Coffee Grounds Oil.Foods (Basel, Switzerland) · 2025Article
- Trends and Future Perspectives of Polysaccharide-Based Bigels from Seeds, Vegetable Oils, and Waxes: A Bibliometric Review.Gels (Basel, Switzerland) · 2025Review
- Efficacy Study of Propolis Eutectic Extract in Gel Formulations for the Treatment of Bacterial Skin Diseases in Dogs.Animals : an open access journal from MDPI · 2025Article
- Bigels as Delivery Systems: Potential Uses and Applicability in Food.Gels (Basel, Switzerland) · 2023Review
- Editorial on the Special Issue "Advances in Cellulose-Based Hydrogels".Gels (Basel, Switzerland) · 2022Article
- Effect of Potato Starch Hydrogel:Glycerol Monostearate Oleogel Ratio on the Physico-Rheological Properties of Bigels.Gels (Basel, Switzerland) · 2022Article
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Authors and funding
5 authors.
Funding
Abstract
Bigels are biphasic semisolid systems that have been explored as delivery vehicles in the food and pharmaceutical industries. These formulations are highly stable and have a longer shelf-life than emulsions. Similarly, cellulose-based hydrogels are considered to be ideal for these formulations due to their biocompatibility and flexibility to mold into various shapes. Accordingly, in the present study, the properties of an optimized guar gum hydrogel and sesame oil/candelilla wax oleogel-based bigel were tailored using date palm-derived cellulose nanocrystals (dp-CNC). These bigels were then explored as carriers for the bioactive molecule moxifloxacin hydrochloride (MH). The preparation of the bigels was achieved by mixing guar gum hydrogel and sesame oil/candelilla wax oleogel. Polarizing microscopy suggested the formation of the hydrogel-in-oleogel type of bigels. An alteration in the dp-CNC content affected the size distribution of the hydrogel phase within the oleogel phase. The colorimetry studies revealed the yellowish-white color of the samples. There were no significant changes in the FTIR functional group positions even after the addition of dp-CNC. In general, the incorporation of dp-CNC resulted in a decrease in the impedance values, except BG3 that had 15 mg dp-CNC in 20 g bigel. The BG3 formulation showed the highest firmness and fluidity. The release of MH from the bigels was quasi-Fickian diffusion mediated. BG3 showed the highest release of the drug. In summary, dp-CNC can be used as a novel reinforcing agent for bigels.
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