ReviewDentistry journal2022
Periodontal and Peri-Implant Health Status in Traditional vs. Heat-Not-Burn Tobacco and Electronic Cigarettes Smokers: A Systematic Review.
Review in Dentistry journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06480877 (Effect of Aerosol From Tobacco Heating System and Tobacco Cigarette Smoke on Periodontal Tissues and Its Specific Microbiome), which is not on this map. Cited by 33 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Aerosol From Tobacco Heating System and Tobacco Cigarette Smoke on Periodontal Tissues and Its Specific Microbiome
Who cites it
33 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Effect of Vaping on Treatment Outcomes in Patients With Gingivitis, Periodontitis, and/or Peri-Implant Disease: A Systematic Review.Clinical and experimental dental research · 2026Pooled it
- Health impacts of electronic nicotine delivery systems: an umbrella review of systematic reviews.BMJ open · 2025Pooled it
- The impact of e-cigarette use on periodontal health: a systematic review and meta-analysis.Evidence-based dentistry · 2025Pooled it
- The Effect of Nicotine-Containing Products on Peri-Implant Tissues: A Systematic Review and Network Meta-Analysis.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024Pooled it
- Periodontal and Peri-Implant Status Among Users of Different Inhaled Tobacco and Nicotine Products: A Systematic Review.Dentistry journal · 2026Review
- Longitudinal comparison of peri-implant clinical and radiographic parameters between e-cigarette users and conventional cigarette smokers.BMC oral health · 2026Article
- Article
- Selected Population-based Oral Health Assessment Following Usage of E-Cigarettes and Combustible Cigarettes.Oral health & preventive dentistry · 2025Article
- The Impact of Cigarette Smoking and Vaping Use on the Development and Progression of Periodontitis: A Systematic Review.Health science reports · 2025Review
- Smoking Knowledge and Behaviors in a Population of Italian Students in Dental Hygiene or Other Health Disciplines.Healthcare (Basel, Switzerland) · 2025Article
- Effectiveness and Adherence of Pharmacological vs. Non-Pharmacological Technology-Supported Smoking Cessation Interventions: An Umbrella Review.Healthcare (Basel, Switzerland) · 2025Review
- Effects of different curing methods on the color stability of composite resins.Restorative dentistry & endodontics · 2024Article
- Tobacco-enhanced biofilm formation by Porphyromonas gingivalis and other oral microbes.Molecular oral microbiology · 2024Review
- Peri-Implantitis-Associated Microbiota before and after Peri-Implantitis Treatment, the Biofilm "Competitive Balancing" Effect: A Systematic Review of Randomized Controlled Trials.Microorganisms · 2024Review
- Evaluating the Effects of Cigarette Smoking and Heated Tobacco Products on Hard Dental Tissues: A Comparative Histological and Colorimetric Analysis.Clinical and experimental dental research · 2024Article
- Periodontitis in Psoriatic Patients: Epidemiological Insights and Putative Etiopathogenic Links.Epidemiologia (Basel, Switzerland) · 2024Review
- Oral and Extra-Oral Manifestations of Hypersensitivity Reactions in Orthodontics: A Comprehensive Review.Journal of functional biomaterials · 2024Review
- Longitudinal Observation of Micromotion upon Loading of Implant-Abutment Connection.Bioengineering (Basel, Switzerland) · 2024Article
- Microbiota of Peri-Implant Healthy Tissues, Peri-Implant Mucositis, and Peri-Implantitis: A Comprehensive Review.Microorganisms · 2024Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present systematic review was to evaluate and possibly differentiate the effects of traditional cigarettes, heat-not-burn tobacco, and electronic cigarettes on periodontal and peri-implant health status. Electronic cigarettes and heat-not-burn tobacco have become very popular in recent years and have been proposed to consumers as a safer alternative to conventional tobacco smoke, although their effect on periodontal and peri-implant health remains unclear. The study protocol was developed according to PRISMA guidelines, and the focus question was formulated according to the PICO strategy. A literature search was conducted across PubMed/MEDLINE and the COCHRANE library from 2003 to April 2022. From the 1935 titles initially identified, 18 articles were finally included in the study and extracted data were qualitatively synthesized. It may be carefully concluded that e-cigarettes may cause attenuated clinical inflammatory signs of periodontitis and, hypothetically, of peri-implantitis when compared to conventional tobacco smoke. Both alternative smoking products, containing nicotine, may likewise exert negative effects on periodontal and peri-implant health, as demonstrated by in vitro studies. Further investigations are needed to assess the impact of electronic cigarettes and heat-not-burn tobacco products on periodontal and peri-implant health status.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.