Evidence map›Paper›PMID 35735604›Full record

ArticleClocks & sleep2022

Effect of Modified Yukmijihwang-Tang on Sleep Quality in the Rat.

SunYoung Lee, Hun-Soo Lee, Minsook Ye, Min-A Kim, Hwajung Kang, Sung Ja Rhie, Mi Young Lee, In Chul Jung, In-Cheol Kang, Insop Shim

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clocks & sleep, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

SunYoung LeeDepartment of Physiology, College of Medicine, Kyung Hee University, Seoul 02447, Korea.
Hun-Soo LeeDepartment of Neuropsychiatry, College of Korean Medicine, Daejeon University, Daejeon 34520, Korea.
Minsook YeDepartment of Physiology, College of Medicine, Kyung Hee University, Seoul 02447, Korea.
Min-A KimBioChip Research Center, Department of Biological Science, College of Biological Science, Hoseo University, Asan 31499, Korea.
Hwajung KangBioChip Research Center, Department of Biological Science, College of Biological Science, Hoseo University, Asan 31499, Korea.
Sung Ja RhieDepartment of Beauty Design, Halla University, Wonju 26404, Korea.
Mi Young LeeKorea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, Korea.
In Chul JungDepartment of Neuropsychiatry, College of Korean Medicine, Daejeon University, Daejeon 34520, Korea.ORCID 0000-0001-7245-4990
In-Cheol KangBioChip Research Center, Department of Biological Science, College of Biological Science, Hoseo University, Asan 31499, Korea.
Insop ShimDepartment of Physiology, College of Medicine, Kyung Hee University, Seoul 02447, Korea.ORCID 0000-0002-8014-9782
Hoseo University · KRKyung Hee University · KRDaejeon University · KRHalla University · KRKorea Institute of Oriental Medicine · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many plants have been used in Korean medicine for treating insomnia. However, scientific evidence for their sedative activity has not been fully investigated. Thus, this study was carried out to investigate the sedative effects of the extracts of medicinal plants, including Yukmijihwang-tang and its various modified forms through the 5-HT2c receptor binding assay, and to further confirm its sleep-promoting effects and the underlying neural mechanism in rats utilizing electroencephalography (EEG) analysis. Enzyme-linked immunosorbent assay (ELISA) was used to measure serotonin (5-HT) in the brain. The water extracts of modified Yukmijihwang-tang (YmP) displayed binding affinity to the 5-HT2C receptor (IC

Indexed as

5-HT2c receptor binding assayelectroencephalography (EEG)sleepventrolateral preoptic nucleus (VLPO)Yukmijihwang-tang (Ym)

Identifiers

PMID35735604
PMCPMC9221690
OpenAlexW4281963108

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.