Evidence map›Paper›PMID 35735531›Full record

ArticleBiosensors2022

Peripheral Nerve Injury Induces Changes in the Activity of Inhibitory Interneurons as Visualized in Transgenic GAD1-GCaMP6s Rats.

Vijai Krishnan, Lauren C Wade-Kleyn, Ron R Israeli, Galit Pelled

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Vijai KrishnanDepartment of Mechanical Engineering, Michigan State University, East Lansing, MI 48824, USA.
Lauren C Wade-KleynNeuroscience Program, Michigan State University, East Lansing, MI 48824, USA.
Ron R IsraeliDepartment of Biomedical Engineering, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0001-8038-2050
Galit PelledDepartment of Mechanical Engineering, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0003-2692-2882
Michigan State University · US

Funding

The Role of the Transcallosal Pathway in Neuroplasticity Following Nerve InjuryR01NS072171 · NINDS · MICHIGAN STATE UNIVERSITY · PI PELLED, GALIT · 2010 to 2019
$3.5M
Bioengineering a novel electromagnetic perspective gene as a tool for wireless control of excitable cellsR01NS098231 · NINDS · MICHIGAN STATE UNIVERSITY · PI GILAD, ASSAF A, PELLED, GALIT · 2017 to 2021
$2.6M
NIH HHS R01NS072171NIH HHS R01NS098231NINDS NIH HHS R01 NS072171NINDS NIH HHS R01 NS098231
6 · The paper itself

Abstract

Peripheral nerve injury induces cortical remapping that can lead to sensory complications. There is evidence that inhibitory interneurons play a role in this process, but the exact mechanism remains unclear. Glutamate decarboxylase-1 (GAD1) is a protein expressed exclusively in inhibitory interneurons. Transgenic rats encoding GAD1-GCaMP were generated to visualize the activity in GAD1 neurons through genetically encoded calcium indicators (GCaMP6s) in the somatosensory cortex. Forepaw denervation was performed in adult rats, and fluorescent Ca

Indexed as

Glutamate DecarboxylasePeripheral Nerve InjuriesAnimalsInterneuronsRatsRats, TransgenicSomatosensory CortexGlutamate Decarboxylasecalcium imagingcorpus callosumpainplasticityrehabilitationsomatosensory cortex

Identifiers

PMID35735531
PMCPMC9221547
OpenAlexW4281781737

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.