ReviewBioengineering (Basel, Switzerland)2022
Biodegradable and Biocompatible Adhesives for the Effective Stabilisation, Repair and Regeneration of Bone.
Review in Bioengineering (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Research Progress in Biomedical Materials.Biomolecules · 2026Review
- Fibrin Glues: Proteins, Mechanism of Action, Classification, and Application.International journal of molecular sciences · 2025Review
- Wet-adhesive and antibacterial PAH-TPP coacervates with self-mineralizing capability for cranial flap fixation.Bioactive materials · 2025Article
- Mechanical Properties and Functional Assessment of PMMA Bone Cements Modified with Glassy Carbon.Journal of functional biomaterials · 2025Article
- In Vitro Evaluation of a Semi-Autologous Fibrin Sealant for Surgical Applications.Macromolecular bioscience · 2025Article
- Degradable polymer bone adhesives.Fundamental research · 2025Review
- Bioprinted hydrogels in bone regeneration: a bibliometric analysis.Frontiers in pharmacology · 2025Review
- Effect of Ethyl-Cyanoacrylate and Platelet-Rich Fibrin on Fresh Sockets of Rabbits Subjected to Anticoagulant Therapy.Journal of clinical medicine · 2024Article
- Recent advances of chitosan-based composite hydrogel materials in application of bone tissue engineering.Heliyon · 2024Review
- Genetically Engineered Protein-Based Bioadhesives with Programmable Material Properties.ACS applied materials & interfaces · 2023Article
- The Use of Small-Molecule Compounds for Cell Adhesion and Migration in Regenerative Medicine.Biomedicines · 2023Review
- Review
- Bone adhesive materials: From bench to bedside.Materials today. Bio · 2023Review
- Bond Strength and Adhesion Mechanisms of Novel Bone Adhesives.Bioengineering (Basel, Switzerland) · 2023Article
- Percutaneous bone adhesive application for Jones fracture "at-risk" of nonunion or delayed union: a hypothesis.Patient safety in surgery · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
Bone defects and complex fractures present significant challenges for orthopaedic surgeons. Current surgical procedures involve the reconstruction and mechanical stabilisation of complex fractures using metal hardware (i.e., wires, plates and screws). However, these procedures often result in poor healing. An injectable, biocompatible, biodegradable bone adhesive that could glue bone fragments back together would present a highly attractive solution. A bone adhesive that meets the many clinical requirements for such an application has yet to be developed. While synthetic and biological polymer-based adhesives (e.g., cyanoacrylates, PMMA, fibrin, etc.) have been used effectively as bone void fillers, these materials lack biomechanical integrity and demonstrate poor injectability, which limits the clinical effectiveness and potential for minimally invasive delivery. This systematic review summarises conventional approaches and recent developments in the area of bone adhesives for orthopaedic applications. The required properties for successful bone repair adhesives, which include suitable injectability, setting characteristics, mechanical properties, biocompatibility and an ability to promote new bone formation, are highlighted. Finally, the potential to achieve repair of challenging bone voids and fractures as well as the potential of new bioinspired adhesives and the future directions relating to their clinical development are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.