Evidence map›Paper›PMID 35735420›Full record

ArticleCurrent oncology (Toronto, Ont.)2022

Overdetection of Breast Cancer.

Martin J Yaffe, James G Mainprize

Abstract read
In one paragraph

Article in Current oncology (Toronto, Ont.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Analysing Breast Cancer Screening Trends in Rural Saudi Arabia: Vision 2030 Context.Asian Pacific journal of cancer prevention : APJCP · 2026
    Article
  2. Article
  3. Impact of Breast Cancer Screening on 10-Year Net Survival in Canadian Women Age 40-49 Years.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023
    Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Martin J YaffePhysical Sciences Platform, Sunnybrook Research Institute, Toronto, ON M4N3M5, Canada.ORCID 0000-0002-7227-9915
James G MainprizePhysical Sciences Platform, Sunnybrook Research Institute, Toronto, ON M4N3M5, Canada.ORCID 0000-0001-5479-1280

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Overdetection (often referred to as overdiagnosis) of cancer is the detection of disease, such as through a screening program, that would otherwise remain occult through an individual's life. In the context of screening, this could occur for cancers that were slow growing or indolent, or simply because an unscreened individual would have died from some other cause before the cancer had surfaced clinically. The main harm associated with overdetection is the subsequent overdiagnosis and overtreatment of disease. In this article, the phenomenon is reviewed, the methods of estimation of overdetection are discussed and reasons for variability in such estimates are given, with emphasis on an analysis using Canadian data. Microsimulation modeling is used to illustrate the expected time course of cancer detection that gives rise to overdetection. While overdetection exists, the actual amount is likely to be much lower than the estimate used by the Canadian Task Force on Preventive Health Care. Furthermore, the issue is of greater significance in older rather than younger women due to competing causes of death. The particular challenge associated with in situ breast cancer is considered and possible approaches to avoiding overtreatment are suggested.

Indexed as

Breast NeoplasmsMammographyCanadaEarly Detection of CancerFemaleHumansMass Screeningbreast cancerbreast cancer screeningCanadian National Breast Screening Studymicrosimulationoverdetectionoverdiagnosisovertreatment

Identifiers

PMID35735420
PMCPMC9222123

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.