Evidence map›Paper›PMID 35735376›Full record

ArticleBehavioral sciences (Basel, Switzerland)2022

The Impact of Chronic Unpredictable Mild Stress-Induced Depression on Spatial, Recognition and Reference Memory Tasks in Mice: Behavioral and Histological Study.

Ghofran Khalid Alqurashi, Emad A Hindi, Mohamed A Zayed, Gamal S Abd El-Aziz, Hani A Alturkistani, Rabee F Ibrahim, Mona Ali Al-Thepyani, Refal Bakhlgi, Noor A Alzahrani, Ghulam Md Ashraf and 1 more

Open access · goldAbstract read
In one paragraph

Article in Behavioral sciences (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
6.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 58 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 2 countries.

Ghofran Khalid AlqurashiNeuroscience Unit, Department of Physiology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Emad A HindiDepartment of Anatomy, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-5794-9976
Mohamed A ZayedPhysiology Department, Faculty of Medicine, King Abdulaziz University, Rabigh 25726, Saudi Arabia.ORCID 0000-0001-7064-183X
Gamal S Abd El-AzizDepartment of Anatomy, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Hani A AlturkistaniDepartment of Anatomy, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Rabee F IbrahimDepartment of Anatomy, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Mona Ali Al-ThepyaniPre-Clinical Research Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Refal BakhlgiPre-Clinical Research Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0003-0102-0057
Noor A AlzahraniPre-Clinical Research Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Ghulam Md AshrafPre-Clinical Research Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-9820-2078
Badrah S AlghamdiNeuroscience Unit, Department of Physiology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-9411-3609
King Abdulaziz University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Depression-induced cognitive impairment has recently been given more attention in research. However, the relationship between depression and different types of memory is still not clear. Chronic unpredictable mild stress (CUMS) is a commonly used animal model of depression in which animals are exposed to chronic unpredictable environmental and psychological stressors, which mimics daily human life stressors. This study investigated the impact of different durations of CUMS on various types of memory (short- and long-term spatial memory and recognition memory) and investigated CUMS' impact on the ultrastructural level by histological assessment of the hippocampus and prefrontal cortex. Twenty male C57BL/J6 mice (6 weeks old, 21.8 ± 2 g) were randomly divided into two groups (

Indexed as

anxietydepressionrecognition memoryspatial memorystress

Identifiers

PMID35735376
PMCPMC9219659
OpenAlexW4281629247

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.