Evidence map›Paper›PMID 35734935›Full record

ArticleJournal of intellectual disability research : JIDR2022

Comprehensive cardiopulmonary profile of individuals with Down syndrome.

V D Y Beck, S O Wee, E C Lefferts, B A Hibner, L C Burton, T Baynard, B Fernhall, T I M Hilgenkamp

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of intellectual disability research : JIDR, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

V D Y BeckDepartment of Physical Therapy, University of Nevada - Las Vegas, Las Vegas, NV, USA.ORCID 0000-0002-2310-3331
S O WeeDepartment of Kinesiology, California State University San Bernardino, San Bernardino, CA, USA.ORCID 0000-0002-3485-4405
E C LeffertsDepartment of Kinesiology, Iowa State University, Ames, IA, USA.
B A HibnerIntegrative Physiology Laboratory, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL, USA.
L C BurtonDepartment of Health and Kinesiology, College of Health and Human Sciences, Purdue University, West Lafayette, IN, USA.
T BaynardIntegrative Physiology Laboratory, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL, USA.
B FernhallIntegrative Physiology Laboratory, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL, USA.
T I M HilgenkampDepartment of Physical Therapy, University of Nevada - Las Vegas, Las Vegas, NV, USA.ORCID 0000-0001-9882-163X
University of Illinois Chicago · USUniversity of Nevada, Las Vegas · USCalifornia State University, San Bernardino · USIowa State University · USPurdue University West Lafayette · US

Funding

Central & Peripheral blood flow regulation in individuals with Down syndromeK99HD092606 · NICHD · UNIVERSITY OF ILLINOIS AT CHICAGO · PI HILGENKAMP, THESSA · 2017 to 2018
$200k
NICHD NIH HHS 5K99HD092606NICHD NIH HHS K99 HD092606
6 · The paper itself

Abstract

backgroundIndividuals with Down syndrome (DS) have low levels of cardiorespiratory fitness and previous studies have shown that these low levels of fitness have a physiological cause. During exercise, the cardiovascular, ventilatory and muscular systems are simultaneously active. While individual parameters of these systems have been investigated in DS before, the interaction between these parameters and systems have not been discussed in detail. Doing so may provide important insight regarding the aetiology of low cardiorespiratory fitness and which parameters of the cardiovascular, pulmonary and muscular systems are altered in individuals with DS compared with their peers without DS.

methodsCardiopulmonary exercise tests were performed in healthy adults with and without DS. Parameters related to the cardiovascular, ventilatory and muscular systems were collected until VO

resultsIndividuals with DS showed lower peak values for all collected outcomes (P ≤ 0.001) compared with those without DS, except for ventilatory threshold as a percentage of maximal oxygen uptake and V

conclusionsOur results show that individuals with DS present impairments across the cardiovascular, ventilatory and muscular aspects of the cardiopulmonary system.

Indexed as

Cardiorespiratory FitnessDown SyndromeAdultExerciseExercise TestHumansOxygen ConsumptionDown syndromefitnessmaximal oxygen uptakexercise testing

Identifiers

PMID35734935
PMCPMC13541654
OpenAlexW4283322735

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.