Evidence map›Paper›PMID 35734904›Full record

ReviewHuman reproduction (Oxford, England)2022

Age-related fertility decline: is there a role for elective ovarian tissue cryopreservation?

Lorraine S Kasaven, Srdjan Saso, Natalie Getreu, Helen O'Neill, Timothy Bracewell-Milnes, Fevzi Shakir, Joseph Yazbek, Meen-Yau Thum, James Nicopoullos, Jara Ben Nagi and 3 more

Open access · bronzeAbstract readReview
In one paragraph

Review in Human reproduction (Oxford, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Lorraine S KasavenWest London Gynaecological Cancer Centre, Hammersmith Hospital, Imperial College NHS Trust, London, UK.ORCID 0000-0002-1752-5220
Srdjan SasoWest London Gynaecological Cancer Centre, Hammersmith Hospital, Imperial College NHS Trust, London, UK.
Natalie GetreuTranslational Ovarian Physiology and Pathophysiology, Institute for Women's Health, University College London, London, UK.
Helen O'NeillGenome Editing and Reproductive Genetics Group, Institute for Women's Health, University College London, London, UK.
Timothy Bracewell-MilnesLister Fertility Clinic, The Lister Hospital, London, UK.ORCID 0000-0001-9827-4816
Fevzi ShakirRoyal Free London NHS Foundation Trust, London, UK.
Joseph YazbekWest London Gynaecological Cancer Centre, Hammersmith Hospital, Imperial College NHS Trust, London, UK.
Meen-Yau ThumLister Fertility Clinic, The Lister Hospital, London, UK.
James NicopoullosLister Fertility Clinic, The Lister Hospital, London, UK.
Jara Ben NagiCentre for Reproductive and Genetic Health, London, UK.
Paul HardimanRoyal Free London NHS Foundation Trust, London, UK.
Cesar Diaz-GarciaIVI London, IVIRMA Global, London, UK.
Benjamin P JonesWest London Gynaecological Cancer Centre, Hammersmith Hospital, Imperial College NHS Trust, London, UK.ORCID 0000-0002-0391-0443
Hammersmith Hospital · GBLister Hospital · GBUniversity College London · GBRoyal Free London NHS Foundation Trust · GBMRC Centre for Reproductive Health · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Age-related fertility decline (ARFD) is a prevalent concern amongst western cultures due to the increasing age of first-time motherhood. Elective oocyte and embryo cryopreservation remain the most established methods of fertility preservation, providing women the opportunity of reproductive autonomy to preserve their fertility and extend their childbearing years to prevent involuntary childlessness. Whilst ovarian cortex cryopreservation has been used to preserve reproductive potential in women for medical reasons, such as in pre- or peripubertal girls undergoing gonadotoxic chemotherapy, it has not yet been considered in the context of ARFD. As artificial reproductive technology (ART) and surgical methods of fertility preservation continue to evolve, it is a judicious time to review current evidence and consider alternative options for women wishing to delay their fertility. This article critically appraises elective oocyte cryopreservation as an option for women who use it to mitigate the risk of ARFD and introduces the prospect of elective ovarian cortex cryopreservation as an alternative.

Indexed as

CryopreservationFertility PreservationFemaleFertilityHumansOocytesOvaryage-related fertility declineelective oocyte cryopreservationfertility preservationovarian tissue cryopreservationvitrification

Identifiers

PMID35734904
PMCPMC9433842
OpenAlexW4283329052

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.