ArticleAnnals of medicine and surgery (2012)2022
Dengue encephalitis featuring "double-doughnut" sign - A case report.
Article in Annals of medicine and surgery (2012), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- The varying neuroradiological manifestations of pediatric dengue central nervous system infection: a pictorial review from Pakistan with literature correlation.Pediatric radiology · 2026Review
- 소아 신경영상에서 보이는 비선천성 원인의 영상 소견: 임상 화보.Journal of the Korean Society of Radiology · 2026Review
- Dengue encephalitis: what's new?Current opinion in infectious diseases · 2025Review
- Severe dengue encephalitis showcasing the "double doughnut sign" on MRI: A case report.Radiology case reports · 2025Article
- Metamorphosis of Double Doughnut Sign to Trilaminar Sign: Evolving Neuroimaging Spectrum of Acute Necrotizing Encephalopathy.Annals of Indian Academy of Neurology · 2025Article
- Decoding dengue's neurological assault: insights from single-cell CNS analysis in an immunocompromised mouse model.Journal of neuroinflammation · 2025Article
- Dying From Dengue Encephalitis in the Absence of DHF: A Case Report.Case reports in infectious diseases · 2025Article
- An Intriguing Case of Expanded Dengue Syndrome With Co-existing Encephalitis, Pancreatitis, and Hepatitis: The Classic Thalamic "Double-Doughnut" Sign Revisited.The Neurohospitalist · 2024Article
- Primary infection of BALB/c mice with a dengue virus type 4 strain leads to kidney injury.Memorias do Instituto Oswaldo Cruz · 2023Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Dengue is a common febrile illness caused by Dengue virus and spread by Case presentation: The patient presented with complains of fever, vomiting, weakness in all limbs and difficulty in speech. Neurological examination revealed bilateral horizontal gaze palsy with impaired oculo-cephalic reflex, bulbar dysarthria and quadriplegia with bilateral planters up-going. Laboratory reported anemia, thrombocytopenia and positive NS1 antigen while excluding other tropical and immunological diseases. Brain MRI revealed extensive thalamic involvement as unique "double-doughnut" sign along with lesions in brainstem. The patient received supportive treatment in intensive unit and was discharged following improvement in clinical condition and laboratory reports. Clinical discussion: Dengue can infect the central nervous system directly as encephalitis or can have neurological consequences following multi-organ dysfunction and shock as encephalopathy or post-infection immunological syndromes as Guillain-Barré Syndrome or cerebrovascular complications or dengue muscle dysfunction. The MRI appearance of "double-doughnut" sign points towards dengue encephalitis in appropriate setting. Conclusion: A high index of suspicion is required to make a diagnosis of dengue encephalitis. The "double-doughnut" sign in MRI sequences has the potential to become a diagnostic marker for dengue encephalitis.
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Registered trials
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