ArticleAnnals of medicine and surgery (2012)2022
Severe microcytosis in a hemoglobin E/Β-thalassemia patient with signs of iron deficiency: A case report.
Article in Annals of medicine and surgery (2012), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Characterization and risk assessment of HbF elevation in non-thalassemia hematologic disease patients in Guangdong region.Annals of hematology · 2025Article
- An Indonesian adolescent with Turner syndrome and β-thalassemia in low-resource setting: A case report and literature review article.Annals of medicine and surgery (2012) · 2022Article
- Clinical pathology aspect on diagnosis cholelithiasis in β-Thalassemia patient: A case report.Annals of medicine and surgery (2012) · 2022Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: β-thalassemia is a hereditary disorder characterized by a decrease in the synthesis of β-globin chains that decreases hemoglobin in erythrocytes, low erythrocyte production, and anemia. Case presentation: A 6-year-old girl came with complaints of paleness for one week. Physical examination showed vital signs within normal limits, conjunctival anemia, and hepatomegaly. Investigations: HGB 5.4 g/dL, MCV 44.5 fL, MCH 15.5 pg, MCHC 34.8 g/dL, RDW-CV 29.2%, WBC 4,770/μL, PLT 2,728,000/μL, Serum iron 29 g/dL, TIBC 217 g/dL and transferrin saturation of 13.36%. Peripheral blood smears showed target cells, teardrop cells, ovalocytes, fragmentocytes, cigar cells, and pseudothrombocytosis by automated hematology tools caused by the misinterpretation of small erythrocytes as platelets. Hemoglobin electrophoresis showed a decrease in HbA (4.9%), as well as an increase in HbF (18.3%), HbE (70.5%), and HbA2 (6.3%). The patient was diagnosed with β-thalassemia. Discussion: Thalassemia with severe microcytosis suggests possible coexistence with iron deficiency. A complete iron profile examination is required in these patients to ensure appropriate and comprehensive medical management. Conclusion: Iron profile examination plays an essential role in the management and diagnosis of β-thalassemia patients.
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