ArticleAnnals of medicine and surgery (2012)2022
The effect of epinephrine and methylprednisolone on cardiac arrest patients.
Article in Annals of medicine and surgery (2012), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Efficacy and safety of corticosteroids in cardiac arrest: a systematic review, meta-analysis and trial sequential analysis of randomized control trials.Critical care (London, England) · 2023Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Cardiopulmonary resuscitation (CPR) involves organized procedures performed on patients with cardiac arrest. CPR method and techniques can determine neurological outcomes of the patients. The aim of this study is to investigate the effect of epinephrine in combination with methylprednisolone on neurological complications and the need for vasopressor after resuscitation in patients with cardiac and respiratory arrest. Methods: In this randomized control clinical trial, patients referred to (XXX) who suffered from cardiac arrest and required CPR were included. Patients were divided into two groups; intervention (methylprednisolone + epinephrine) and placebo (epinephrine + placebo). Patients' information was completed in a questionnaire based on demographic information, main objectives and important variables (neurological complication and the need for vasopressor) and SPSSv21 was used for statistical analysis. Results: A total of 347 patients were included in the study. The intervention and control group were not significantly different in terms of gender, age systolic and diastolic blood pressure, p > 0.05. CPC scores were also not significantly different among the two groups, p > 0.05.131 patients (37.8%) needed vasopressor after the intervention and 216 patients (62.2%) did not need vasopressor. The two groups were significantly different in terms of intervention (P = 0.021). Conclusion: Glucocorticoid, methylprednisolone does not reduce the risk of neurological complications following CPR in cardiac arrest patients.
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Registered trials
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